Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.

Annals of the Rheumatic Diseases
Anne HinksWendy Thomson

Abstract

There is strong evidence suggesting that juvenile idiopathic arthritis (JIA) shares many susceptibility loci with other autoimmune diseases. To investigate variants robustly associated with type 1 diabetes (T1D) or coeliac disease (CD) for association with JIA. Sixteen single-nucleotide polymorphisms (SNPs) already identified as susceptibility loci for T1D/CD were selected for genotyping in patients with JIA (n=1054) and healthy controls (n=3129). Genotype and allele frequencies were compared using the Cochrane-Armitage trend test implemented in PLINK. One SNP in the LPP gene, rs1464510, showed significant association with JIA (p(trend)=0.002, OR=1.18, 95% CI 1.06 to 1.30). A second SNP, rs653178 in ATXN2, also showed nominal evidence for association with JIA (p(trend)=0.02, OR=1.13, 95% CI 1.02 to 1.25). The SNP, rs17810546, in IL12A showed subtype-specific association with enthesitis-related arthritis (ERA) subtype (p(trend)=0.005, OR=1.88, 95% CI 1.2 to 2.94). Evidence for a novel JIA susceptibility locus, LPP, is presented. Association at the SH2B3/ATXN2 locus, previously reported to be associated with JIA in a US series, also supports this region as contributing to JIA susceptibility. In addition, a subtype-specific associ...Continue Reading

References

Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nadia DubéMichel L Tremblay
Nov 6, 2007·Nature Genetics·Wendy ThomsonJane Worthington
Sep 17, 2008·Nature Genetics·Anne BartonJane Worthington
Oct 15, 2008·Human Molecular Genetics·Guillaume Lettre, John D Rioux
Dec 17, 2008·The New England Journal of Medicine·Deborah J SmythJohn A Todd
Jan 1, 2009·Arthritis and Rheumatism·Anne HinksUNKNOWN British Society of Paediatric and Adolescent Rheumatology Study Group
Feb 28, 2009·Arthritis and Rheumatism·H M AlbersM W Schilham
Aug 4, 2009·Human Molecular Genetics·Marieke J H CoenenAlexandra Zhernakova
Aug 4, 2009·Human Molecular Genetics·C P GarnerS L Neuhausen
Aug 14, 2009·Annals of the Rheumatic Diseases·Anne HinksWendy Thomson

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Citations

Mar 2, 2011·Zeitschrift für Rheumatologie·U Wagner
Mar 19, 2013·Rheumatology·Elizabeth J CoulsonHelen E Foster
Aug 2, 2011·Dermatology Research and Practice·Naoki OisoAkira Kawada
Feb 7, 2015·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Claudia P CabreraMark J Caulfield
Feb 18, 2017·International Journal of Environmental Research and Public Health·Shi-Qi HuangChun-Xia Jing
Apr 28, 2017·Biochemistry·Grace A R ThieleLouise K Charkoudian
Feb 25, 2017·Archives of Disease in Childhood·Andrea Skrabl-BaumgartnerJörg Jahnel
Aug 20, 2016·Nature Communications·Harvind S ChahalKavita Y Sarin
Dec 17, 2011·The Journal of Rheumatology·Heini PohjankoskiAnneli Savolainen
Nov 18, 2018·The Journal of Rheumatology·Amanda M EudyMegan E B Clowse
Mar 2, 2013·Scandinavian Journal of Gastroenterology·Francesco De MaddiDonato Rigante
Dec 14, 2018·Acta Medica (Hradec Králové)·Lenka TuroňováKlára Martinásková

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Methods Mentioned

BETA
genotyping

Software Mentioned

QUANTO
PLINK

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