Investigation of uncertainties in image registration of cone beam CT to CT on an image-guided radiotherapy system

Physics in Medicine and Biology
J R SykesD I Thwaites

Abstract

Methods of measuring uncertainties in rigid body image registration of fan beam computed tomography (FBCT) to cone beam CT (CBCT) have been developed for automatic image registration algorithms in a commercial image guidance system (Synergy, Elekta, UK). The relationships between image registration uncertainty and both imaging dose and image resolution have been investigated with an anthropomorphic skull phantom and further measurements performed with patient images of the head. A new metric of target registration error is proposed. The metric calculates the mean distance traversed by a set of equi-spaced points on the surface of a 5 cm sphere, centred at the isocentre when transformed by the residual error of registration. Studies aimed at giving practical guidance on the use of the Synergy automated image registration, including choice of algorithm and use of the Clipbox are reported. The chamfer-matching algorithm was found to be highly robust to the increased noise induced by low-dose acquisitions. This would allow the imaging dose to be reduced from the current clinical norm of 2 mGy to 0.2 mGy without a clinically significant loss of accuracy. A study of the effect of FBCT slice thickness/spacing and CBCT voxel size showe...Continue Reading

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Citations

May 26, 2011·Biomedical Imaging and Intervention Journal·Kyt SeetJ Van Dyk
Jun 2, 2011·Medical Physics·Jidong HouWarren D D'Souza
Jan 20, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Simon van KranenJan-Jakob Sonke
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May 3, 2019·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Yuliang HuangYibao Zhang
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Sep 30, 2016·Journal of Applied Clinical Medical Physics·Jeffrey BarberDavid I Thwaites
Aug 22, 2017·Nihon Hoshasen Gijutsu Gakkai zasshi·Takuya TaniguchiRyousyuu Maejima

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