PMID: 11328416May 1, 2001Paper

Investigation of women with endometrial carcinoma using serum vascular endothelial growth factor (VEGF) measurement

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
R J GornallR P Woolas

Abstract

This study assessed whether serum VEGF measurement in women presenting with endometrial cancer could predict advanced stage disease. Preoperative sera from 37 women undergoing laparotomy for suspected endometrial cancer were assayed for VEGF, CA125 and platelet count. Significant positive correlation was shown between VEGF and platelet levels (P = 0.003, r = 0.477). However, no correlation was demonstrated between VEGF and stage overall, and no significant difference was shown between those with early (stage 1A/1B, n = 20) compared to those with advanced (stage >1B, n = 13) or disseminated (stage >2, n = 7) disease. Serum VEGF measurement was not beneficial in the preoperative assessment of stage in patients with endometrial carcinoma. Strong correlation with platelet levels suggests that this is one of the sources of VEGF measured.

Citations

Nov 10, 2013·Gynecologic Oncology·Akila N ViswanathanUrsula Matulonis
Jan 24, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Angiolo GadducciAndrea Riccardo Genazzani
Dec 8, 2010·Critical Reviews in Oncology/hematology·Angiolo GadducciAndrea Riccardo Genazzani
Jan 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sami K SaarelainenJohanna U Mäenpää
May 13, 2020·Journal of Cancer Research and Clinical Oncology·Karin AbbinkFred C G J Sweep

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