Investigation on design of stable etoposide-loaded PEG-PCL micelles: effect of molecular weight of PEG-PCL diblock copolymer on the in vitro and in vivo performance of micelles

Drug Delivery
Mukesh UkawalaR S R Murthy

Abstract

In the present study, six different molecular weight diblock copolymer of methoxy poly (ethylene glycol)-b-poly (ε-caprolactone) (MPEG-PCL) were synthesized and characterized and was used for fabrication of etoposide-loaded micelles by nanoprecipitation technique. The particle size and percentage drug entrapment of prepared micelles were found to be dependent on the molecular weight of PCL block and drug to polymer ratio. The maximum drug loading of 5.32% was found in micellar formulation MPEG5000-PCL10000, while MPEG2000-PCL2000 exhibited 2.73% of maximum drug loading. A variation in the fixed aqueous layer thickness and PEG surface density of micellar formulations was attributed to difference in MPEG molecular weight and interaction of PEG and PCL block of copolymer. The MPEG2000-PCL2000 micelles demonstrated poor in vitro stability among other micellar formulations, due to its interaction with bovine serum albumin and immediate release of drug from micelles. Furthermore, plain etoposide and MPEG2000-PCL2000 micelles exhibited greater extent of hemolysis, due to presence of surfactants and faster release of drug from micelles, respectively. The biodistribution studies carried out on Ehrlich ascites tumor-bearing Balb/C mice c...Continue Reading

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Citations

Feb 20, 2015·Drug Delivery·Haiqun ZhangGuangxi Zhai
May 5, 2016·Drug Development and Industrial Pharmacy·Wenjun ChenShuli Wang
Oct 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·A Al SamadB Nottelet
Jun 6, 2020·Molecular Pharmaceutics·Qingqing LiShing Fung Chow
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May 26, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Philip GrossenJörg Huwyler
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Nidhi RavalRakesh K Tekade
Feb 21, 2019·Biomacromolecules·Jiří TrousilMartin Hrubý

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