Investigation on magnetically controlled delivery of doxorubicin from superparamagnetic nanocarriers of gelatin crosslinked with genipin.

Journal of Materials Science. Materials in Medicine
Jyoti Choubey, A K Bajpai

Abstract

Gelatin (Type B) nanoparticles were prepared by a single W/O emulsion technique and characterized by infrared (IR) spectra, transmission electron micrographs (TEM), surface potential measurements and magnetization studies. Whereas the IR spectra clearly confirmed the presence of gelatin, genipin and doxorubicin in the loaded nanoparticles, the transmission electron micrographs (TEM) image depicts smooth surface, spherical shape and non-uniform size of nanoparticles (up to 100 nm). The prepared nanoparticles were loaded with doxorubicin, a well known anticancer drug, and in vitro release dynamics of entrapped drug was investigated as a function of various experimental factors such as percent loading of the drug, chemical architecture of the nanocarriers, and pH, temperature, ionic strength and nature of the release medium in presence and absence of magnetic field. The nanoparticles were also studied for their water sorption capacity. The drug release process was analyzed kinetically using Ficks power law and a correlation was established between the quantity of released drug and swelling of the nanoparticles.

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Citations

Dec 29, 2010·Journal of Materials Science. Materials in Medicine·A K Bajpai, Rashmi Gupta
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Gholam Reza Mahdavinia, Hossein Etemadi
Apr 3, 2013·Carbohydrate Polymers·Maite Arteche PujanaIssa Katime
Dec 21, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ji-Eon KimDae-Duk Kim
Oct 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ahmed O Elzoghby
Dec 5, 2013·Carbohydrate Polymers·Maite Arteche PujanaIssa Katime
Mar 25, 2019·Pharmaceutics·Constantin MircioiuIon Mircioiu
Feb 6, 2014·Advanced Healthcare Materials·Francesco Canfarotta, Sergey A Piletsky
Mar 18, 2017·Oxidative Medicine and Cellular Longevity·Abida Kalsoom KhanGhulam Murtaza
Nov 7, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Masoud FarshbafRoya Salehi
Mar 10, 2015·International Journal of Biological Macromolecules·P R Sarika, Nirmala Rachel James
Apr 6, 2019·International Journal of Biological Macromolecules·Mohammad Sadegh Amini-FazlKarim Kheiri

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