Investigation on the effects of the atmospheric pressure plasma on wound healing in diabetic rats

Scientific Reports
Sara FathollahKatalin Martits Chalangari

Abstract

It is estimated that 15 percent of individuals with diabetes mellitus suffer from diabetic ulcers worldwide. The aim of this study is to present a non-thermal atmospheric plasma treatment as a novel therapy for diabetic wounds. The plasma consists of ionized helium gas that is produced by a high-voltage (8 kV) and high-frequency (6 kHz) power supply. Diabetes was induced in rats via an intravascular injection of streptozotocin. The plasma was then introduced to artificial xerograph wounds in the rats for 10 minutes. Immunohistochemistry assays was performed to determine the level of transforming growth factor (TGF-β1) cytokine. The results showed a low healing rate in the diabetic wounds compared with the wound-healing rate in non-diabetic animals (P < 0.05). Moreover, the results noted that plasma enhanced the wound-healing rate in the non-diabetic rats (P < 0.05), and significant wound contraction occurred after the plasma treatment compared with untreated diabetic wounds (P < 0.05). Histological analyses revealed the formation of an epidermis layer, neovascularization and cell proliferation. The plasma treatment also resulted in the release of TGF-β1 cytokine from cells in the tissue medium. The findings of this study demons...Continue Reading

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Citations

Jul 22, 2018·Biological Chemistry·Sander BekeschusAnke Schmidt
Jul 26, 2018·Biological Chemistry·Nagendra Kumar KaushikEun Ha Choi
Jul 13, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·Yoonje LeeKyu-Sun Chung
Jul 2, 2019·The International Journal of Lower Extremity Wounds·Fahimeh RezaieHojjat Naderi-Meshkin
Apr 16, 2020·Diagnostics·Rico RutkowskiHans-Robert Metelmann
Jul 28, 2018·Scientific Reports·Priyanka ShawPankaj Attri
Jun 28, 2018·Australasian Physical & Engineering Sciences in Medicine·Kamal M AhmedWalaa F Hassanin
Jun 20, 2018·Scientific Reports·Han Sup UhmEun Ha Choi
Jul 12, 2017·Oxidative Medicine and Cellular Longevity·Ku Youn BaikByoungchoo Park
Oct 3, 2018·Australasian Physical & Engineering Sciences in Medicine·Zahra Shahbazi RadGholamreza Etaati
Aug 26, 2018·Scientific Reports·Rajesh Kumar GandhirajanSander Bekeschus
Feb 2, 2020·Scientific Reports·Nobuhisa YoshikawaHiroaki Kajiyama
Aug 30, 2020·Inflammation·Lucas Buzeli de SouzaThiago Antônio Moretti de Andrade
Apr 6, 2018·Scientific Reports·Maedeh ChatraieBabak Shokri
Aug 11, 2020·Journal of Cancer Research and Clinical Oncology·Swethan AlagaratnamBala Ramesh
Sep 27, 2019·Archives of Biochemistry and Biophysics·Maryam GhasemitareiAnnemie Bogaerts
Mar 4, 2021·Experimental Biology and Medicine·Sung-Tak LeeDae-Seok Hwang
Mar 2, 2021·International Journal of Pharmaceutics·Katie GloverDimitrios A Lamprou
Oct 29, 2017·The Journal of Surgical Research·Yudai NomuraTakeshi Azuma
Apr 16, 2021·The International Journal of Lower Extremity Wounds·Joon M JungChong H Won
Sep 3, 2021·Redox Biology·Sander BekeschusAnke Schmidt
Jan 8, 2022·Journal of Basic and Clinical Physiology and Pharmacology·Raghuvir KeniRekha R Shenoy
Feb 23, 2017··Thomas P. RyanKenneth R. Stalder

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