Investigation on the function tropism of Tiaoqin and Kuqin (different specification of Scutellaria baicalensis) by comparing their curative effect on different febrile disease model.

Journal of Ethnopharmacology
Yongshen RenCaijing He

Abstract

Scutellaria baicalensis (S. baicalensis) is the root of S. baicalensis Georgi. In traditional Chinese medicine it is divided into Tiaoqin (TQ, 1-3 years old) and Kuqin (KQ, more than 3 years old). However, the differences in TQ and KQ efficacy and their exact mechanisms are still unclear. This study aimed to clarify the difference in the efficacy of TQ and KQ in relation to different fever types (damp heat and hyperpyrexia) by using rat models, as well as to determine the primary molecular mechanism. This study compared the compositional content of TQ and KQ by UPLC-MS/MS. Then, rat models of hyperpyrexia (HP, LPS) and damp heat (DH, high-fat and high-sugar diet feeding + fumigation in artificial climate chamber + E. coli injection) were established and their clinical symptoms, blood biochemistry, histopathological sections, cell cytokines and protein expression were compared following treatment with TQ or KQ. Finally, the mechanisms underpinning the differences observed for TQ and KQ were determined by measuring the components of these treatments in different target organs. This study identified 31 compounds in the water extracts of both TQ and KQ, which differed significantly in their relative content. TQ and KQ showed differ...Continue Reading

References

Mar 13, 2003·The Journal of Pharmacy and Pharmacology·Y C HouS L Hsiu
Nov 25, 2003·Anesthesia and Analgesia·Tz-Chong ChouShih-Ping Yang
Jan 31, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y-M ChoM Hirose
Feb 3, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Renzo CaprilliGiovanni Latella
Jul 27, 2007·Nature·R J Xavier, D K Podolsky
Oct 24, 2007·World Journal of Gastroenterology : WJG·Ho-Lam ChungWing-Hung Ko
Aug 24, 2012·Lancet·Ingrid OrdásWilliam J Sandborn
Nov 20, 2012·International Immunopharmacology·Jee Youn KimSang-Bae Han
Dec 25, 2012·International Immunopharmacology·Eui-Baek ByunJae-Hun Kim
May 6, 2016·The New England Journal of Medicine·William J SandbornUNKNOWN TOUCHSTONE Study Group
Sep 1, 2016·Nanoscale Research Letters·Donghyun LeeIl Keun Kwon
Sep 7, 2016·Inflammatory Bowel Diseases·Shirin SedghiFanny Daniel
Mar 21, 2017·Mediators of Inflammation·Taku KuwabaraTerutaka Kakiuchi
Mar 11, 2018·BMC Complementary and Alternative Medicine·Tamires Rocha FalcãoGerlane Coelho Bernardo Guerra
Jun 5, 2018·Biological & Pharmaceutical Bulletin·Satoshi MurakamiHiroaki Araki
Aug 3, 2019·International Journal of Nanomedicine·Maria Talita Pacheco de OliveiraAndressa Bernardi

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