Investigation on the micelle-sensitized Ce(IV)-lornoxicam-Rh B chemiluminescence system and its application.

Journal of Fluorescence
Fang Zhao, Wen-hui Zhao


Based on the micelle synergism mechanism, a simple and sensitive flow injection chemiluminescence (FI-CL) method for the assay of lornoxicam was described. The CL signal generated from the reaction of Ce (IV) with lornoxicam in acidic solution was very weak, while the interfusion of sodium dodecyl benzene sulfonate (SDBS) resulted in a highly CL intensity. Under the optimum experimental conditions, the CL intensity was proportional to lornoxicam concentration over the range 1.0 × 10(-10)-7.3 × 10(-8) g/mL with a detection limit of 4.9 × 10(-11) g/mL (3σ). The relative standard deviation for 11 replicate measurements of 3.0 × 10(-9) g/mL of lornoxicam was 1.9%. The proposed method was successfully applied for the assay of lornoxicam in pharmaceuticals, human serum and urine with excellent recovery. The possible mechanism of CL reaction was also discussed briefly.


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