PMID: 8965101Apr 1, 1996Paper

Investigation on the mitochondrial transfer RNA(Leu)(UUR) in blood cells from patients with cluster headache

Journal of Neurology
P SeibelH Reichmann

Abstract

Various mutations in the mitochondrial tRNA(Leu)(UUR) gene give rise to a variety of neurological disorders. Among these, mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS syndrome) are frequently associated with a tRNA(Leu)(UUR) mutation at nucleotide position 3243 of the mitochondrial DNA. A supplementary clinical feature seen in these patients is headache in early life. Recently, a tRNA(Leu)(UUR) mutation at nucleotide position 3243 has been found in a patient presenting with cluster headache. This led us to examine the mitochondrial genomes of 22 patients presenting with cluster headache. None of the patients harboured the reported tRNA(Leu)(UUR) mutation or any other length variations of the mtDNA. Cluster headache is most likely not causally associated with the A3243G mutation of the mitochondrial DNA.

References

Jan 1, 1992·Neuromuscular Disorders : NMD·M HiranoL P Rowland
Apr 11, 1991·Nucleic Acids Research·J LauberP Seibel
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J M ShoffnerD C Wallace
Apr 29, 1994·Biochemical and Biophysical Research Communications·P SeibelH Reichmann

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Citations

Oct 12, 2012·Molecular Genetics and Genomics : MGG·S Stuart, L R Griffiths
Mar 17, 2001·Current Pain and Headache Reports·A May, P J Goadsby
Apr 29, 2010·Current Pain and Headache Reports·Markus Schürks
Mar 25, 2006·Cephalalgia : an International Journal of Headache·M SparacoM E Bigal
Mar 18, 2008·The Journal of Headache and Pain·Pasquale Montagna
Apr 22, 2004·Lancet Neurology·Michael Bjørn Russell
Nov 16, 2014·Cephalalgia : an International Journal of Headache·Claudia M WellerBoukje de Vries
Feb 15, 2002·Cephalalgia : an International Journal of Headache·J HaanM D Ferrari
Mar 11, 2009·Expert Review of Neurotherapeutics·Christina Sjöstrand
Jun 27, 1998·Current Opinion in Neurology·A May, P J Goadsby
Mar 29, 2019·Cephalalgia : an International Journal of Headache·Kate F GibsonIoannis M Stylianou
May 1, 2003·Expert Review of Neurotherapeutics·Jorine A van VlietJoost Haan

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