Investigation on the possible relationship existing between the HLA-DR gene and attention deficit hyperactivity disorder and/or mental retardation

International Journal of Immunopathology and Pharmacology
A AureliS Di Loreto

Abstract

This study examines the possible relationship existing between the HLA-DR gene and attention deficit hyperactivity disorder (ADHD) and/or mental retardation (MR). The diagnosis of ADHD and mental retardation were established through clinical interviews with the parents, children and teachers, according to the criteria in DSM-IV. HLA-DRB1 genotyping was performed both by polymerase chain reaction-sequence specific primers (PCR-SSP) and by sequence based typing (SBT) in a cohort of 81 affected children and a sample of 100 healthy controls. Here, we report a positive association of HLA-DR4 with ADHD but not with MR. The study adds confirmation to the role of the HLA-DRB1 in the etiology of some types of childhood neuropsychiatric illnesses.

References

Jan 21, 1995·BMJ : British Medical Journal·J M Bland, D G Altman
Oct 1, 1993·Journal of Child Psychology and Psychiatry, and Allied Disciplines·J StevensonJ J Gillis
Jul 1, 1996·Journal of Neuroimmunology·R P WarrenA R Torres
Aug 1, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·P S JensenD P Cantwell
Aug 13, 1998·Journal of Abnormal Child Psychology·C K ConnersJ N Epstein
Jun 11, 1999·Journal of the American Academy of Child and Adolescent Psychiatry·L A RohdeS Tramontina
May 25, 2006·Human Immunology·Anthony R TorresDennis Odell
Nov 1, 2006·Pediatric Neurology·Li-Ching LeeAndrew W Zimmerman
Jan 6, 2007·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·P ScarpaG Bottini

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Citations

Nov 13, 2012·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Mu-Hong ChenYa-Mei Bai
Feb 13, 2013·Journal of Attention Disorders·Mu-Hong ChenYa-Mei Bai
Apr 30, 2017·Psychiatric Genetics·Jameela M A ShinwariNada A Al Tassan
Feb 5, 2014·European Child & Adolescent Psychiatry·Annelies A J VerlaetHuub F J Savelkoul
Feb 21, 2013·European Journal of Human Genetics : EJHG·André MégarbanéDavid Piquemal

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