Investigational agents for treatment of traumatic brain injury

Expert Opinion on Investigational Drugs
Ye XiongMichael Chopp

Abstract

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. To date, there are no pharmacologic agents proven to improve outcomes from TBI because all the Phase III clinical trials in TBI have failed. Thus, there is a compelling need to develop treatments for TBI. The following article provides an overview of select cell-based and pharmacological therapies under early development for the treatment of TBI. These therapies seek to enhance cognitive and neurological functional recovery through neuroprotective and neurorestorative strategies. TBI elicits both complex degenerative and regenerative tissue responses in the brain. TBI can lead to cognitive, behavioral, and motor deficits. Although numerous promising neuroprotective treatment options have emerged from preclinical studies that mainly target the lesion, translation of preclinical effective neuroprotective drugs to clinical trials has proven challenging. Accumulating evidence indicates that the mammalian brain has a significant, albeit limited, capacity for both structural and functional plasticity, as well as regeneration essential for spontaneous functional recovery after injury. A new therapeutic approach is to stimulate neurovascular remodeling by ...Continue Reading

References

Feb 6, 1998·Acta Diabetologica·L Luzi, G Pozza
Oct 3, 1999·Journal of Neurosurgery·N R TemkinH R Winn
Apr 3, 2001·Expert Opinion on Investigational Drugs·A I Maas
Apr 23, 2002·Traffic·Willem StoorvogelGraça Raposo
Jun 4, 2002·Journal of Neurotrauma·Raj K NarayanLorraine Yurkewicz
Jul 10, 2003·Lancet Neurology·Michael Chopp, Yi Li
Dec 17, 2003·Journal of Neurosurgical Anesthesiology·Egon M R DoppenbergRoss Bullock
Jan 7, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Michael Gaetz
Nov 24, 2004·Metabolic Brain Disease·Hannelore EhrenreichAnna-Leena Sirén
Aug 16, 2005·Trends in Molecular Medicine·Allan L GoldsteinHynda K Kleinman
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Ibolja Cernak
Jan 25, 2006·Journal of Neurotrauma·Philip E EmpeyJimmi Hatton
May 30, 2006·Current Pharmaceutical Design·Niklas MarklundTracy K McIntosh
Sep 20, 2006·The Journal of Head Trauma Rehabilitation·Jean A LangloisMarlena M Wald
Oct 3, 2006·Annals of Emergency Medicine·David W WrightDonald G Stein
Oct 3, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Jieli Chen, Michael Chopp
Jan 12, 2007·The Journal of Trauma·Bryan A CottonJohn A Morris
May 1, 2007·Annals of the New York Academy of Sciences·Woong Sun, Hyun Kim
Jun 5, 2007·British Journal of Anaesthesia·I K Moppett
Jul 6, 2007·Journal of the Neurological Sciences·Michael ChoppJing Zhang
Aug 9, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Simon R ClarkNancy J Rothwell
Aug 19, 2007·Journal of Neurosurgery·Asim MahmoodMichael Chopp
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven J Greco, Pranela Rameshwar
Aug 24, 2007·Brain : a Journal of Neurology·Claire L GibsonSean P Murphy
Oct 20, 2007·Annals of the New York Academy of Sciences·David Crockford
Jan 2, 2008·Acta neurochirurgica·B S HarhangiA I R Maas

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Citations

Jun 1, 2016·Worldviews on Evidence-based Nursing·Qiuhua ShenJanet D Pierce
Jan 28, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hong ZhangJinyuan Zhou
Jun 1, 2017·The Journal of Comparative Neurology·Gloria J DeWalt, William D Eldred
Apr 20, 2018·Stroke; a Journal of Cerebral Circulation·Jieli Chen, Michael Chopp
Jan 22, 2019·Journal of Lipid Research·Sergei A NovgorodovTatyana I Gudz
Sep 25, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shan HuangPing Lei
Apr 8, 2020·Antioxidants·Rosalia CrupiDaniela Impellizzeri
Dec 17, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Takerra JohnsonDong Liu
Jun 15, 2019·Neurotoxicity Research·Katarzyna GłombikAgnieszka Basta-Kaim
Jul 1, 2020·Neural Regeneration Research·Chao ZhouChong-Jie Cheng
Dec 27, 2019·Neuroscience and Biobehavioral Reviews·Mujun SunSandy R Shultz
Jan 23, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Adriana Raquel de Almeida da AnunciaçãoMaria Angelica Miglino
Oct 28, 2020·Pediatric Research·Amanda M Dave, Eric S Peeples
Mar 8, 2021·Genomics·Vishal Chavda, Kajal Madhwani
Apr 10, 2021·Frontiers in Neuroscience·Michael K GhiamMichael E Hoffer
May 7, 2021·Journal of Molecular Neuroscience : MN·Komal ThapaAmarjot Kaur
May 2, 2021·The European Journal of Neuroscience·Sushanta Kumar MishraGurudutta Gangenahalli
Feb 3, 2021·Fundamental & Clinical Pharmacology·Dominique LerouetValérie C Besson

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