Investigational agents in immunotherapy: a new horizon for the treatment of multiple myeloma

British Journal of Haematology
Cindy VargaP G Richardson

Abstract

The treatment of multiple myeloma (MM) has gone through several major advances over the last 5 years with the introduction of next generation proteasome inhibitors (PI; carfilzomib, ixazomib) and immunomodulatory derivatives (IMiD; pomalidomide), with these new agents having a substantial impact on patient outcome. However, despite these advances, MM remains a highly resistant disease given its propensity for clonal heterogeneity and its complex interaction with the surrounding bone marrow microenvironment. Almost all patients eventually relapse despite therapeutic responses to a PI, IMiD or both. With the regulatory approval of the monoclonal antibodies Daratumumab and Elotuzumab in 2015, impressive and durable responses are being observed, even in heavily pre-treated patients who have exhausted other therapeutic options, suggesting immunological approaches in this setting have real merit. This review will focus on newer monoclonal antibodies and chimeric-antigen receptor (CAR) T cell strategies currently under investigation and in various stages of clinical development.

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Citations

Nov 30, 2019·Journal of Oncology·Hiroko Nishida, Taketo Yamada
Oct 3, 2018·Antibody Therapeutics·Zoe ShancerTapan K Bera
Feb 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Zoë ShancerIra Pastan
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Sep 22, 2020·Panminerva Medica·Federico VozellaClaudio Cerchione
Mar 21, 2021·Biochemical Pharmacology·Manon LernouxMarc Diederich
Apr 1, 2021·Clinical Lymphoma, Myeloma & Leukemia·Krystal BerginUNKNOWN Australian and New Zealand Myeloma and Related Diseases Registry
Apr 8, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Juana Alonso-TitosDomingo Hernández
May 21, 2021·Bone Marrow Transplantation·Krystal BerginUNKNOWN Australian and New Zealand Myeloma and Related Diseases Registry
Aug 9, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wenxing GuZhiyuan Zhong

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