Investigational anabolic therapies for osteoporosis

Expert Opinion on Investigational Drugs
Ritu TrivediNaibedya Chattopadhyay

Abstract

Anabolic therapy, or stimulating the function of bone-forming osteoblasts, is the preferred pharmacological intervention for osteoporosis. We reviewed bone anabolic agents currently under active investigation. The bone anabolic potential of IGF-I and parathyroid hormone-related protein is discussed in the light of animal data and human studies. We also discuss the use of antagonists of the calcium-sensing receptor (calcilytics) as orally administered small molecules capable of transiently elevating serum parathyroid hormone (PTH). Further, we reviewed novel anabolic agents targeting members of the wingless tail (Wnt) signaling family that regulate bone formation including DKK-1, sclerostin, Thp1, and glycogen synthase kinase 3beta. We have also followed up on the promise shown by beta-blockers in modulating the activity of sympathetic nervous system, thus affecting bone anabolism. We give critical consideration to neutralizing the activity of activin A, a negative regulator of bone mass by soluble activin receptor IIA, as a strategy to promote bone formation. Update on various strategies to promote osteoblast function currently under evaluation. In spite of favorable results in experimental models, none of these strategies has ...Continue Reading

References

Jan 1, 1989·Connective Tissue Research·T L McCarthyE Canalis
Jan 1, 1989·The Journal of Clinical Investigation·E CanalisT L McCarthy
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C M BagiA Sommer
Apr 5, 2000·The Journal of Clinical Investigation·N OgataH Kawaguchi
Aug 11, 2000·Science·S E RossO A MacDougald
Aug 11, 2001·Pharmaceutical Research·A Leone-BayR A Baughman
Nov 24, 2001·Cell·Y GongUNKNOWN Osteoporosis-Pseudoglioma Syndrome Collaborative Group
Jun 11, 2002·The Journal of Biological Chemistry·Christina N BennettOrmond A MacDougald
Nov 7, 2002·Cell·Shu TakedaGerard Karsenty
Nov 19, 2002·Hormone Research·Piet P M M Geusens, Steven Boonen
Apr 18, 2003·Endocrinology and Metabolism Clinics of North America·Mishaela R Rubin, John P Bilezikian
Jun 24, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Philip BabijFrederick Bex
Nov 26, 2003·Journal of the American Society of Nephrology : JASN·Claus P SchmittFranz Schaefer
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·W M DrakeE S Orwoll
Jan 24, 2004·The Journal of Biological Chemistry·Brad SevetsonYang Pan
Jun 18, 2004·Cell Calcium·Shozo YanoNaibedya Chattopadhyay
Aug 21, 2004·Seminars in Reproductive Medicine·Joshua M Hurwitz, Nanette Santoro
Sep 16, 2004·JAMA : the Journal of the American Medical Association·Raymond G SchliengerChristoph R Meier
Oct 12, 2004·Gene·Jennifer J WestendorfTania M Schroeder
Mar 22, 2005·The Journal of Biological Chemistry·Xiaofeng LiDianqing Wu
Mar 31, 2005·Biochemical and Biophysical Research Communications·Akio KanazawaShiro Maeda
Apr 20, 2005·Annals of the New York Academy of Sciences·Wylie ValeSenyon Choe
May 4, 2005·Developmental Cell·Donald A GlassGerard Karsenty
Jun 11, 2005·Bone·Hansjoerg Keller, Michaela Kneissel
Aug 12, 2005·The New England Journal of Medicine·Dennis M BlackUNKNOWN PaTH Study Investigators
Aug 16, 2005·Science·Jeong-Ho HongMichael B Yaffe
Nov 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Philippe Clément-LacroixGeorges Rawadi

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Citations

Nov 13, 2012·Critical Reviews in Eukaryotic Gene Expression·Joseph P BidwellFeng-Chun Yang
Apr 25, 2012·Cellular and Molecular Life Sciences : CMLS·Cyril Thouverey, Joseph Caverzasio
Aug 22, 2015·Expert Opinion on Drug Discovery·Luigi GennariDaniela Merlotti
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Atul Kumar SinghJayesh R Bellare
Apr 17, 2012·Clinical Biochemistry·Bryan K WardThomas Ratajczak
Aug 14, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russell T TurnerUrszula T Iwaniec
Mar 5, 2013·Bioorganic & Medicinal Chemistry·Keiji SaitoSatoru Naito
Apr 8, 2016·Expert Opinion on Pharmacotherapy·Luigi GennariDaniela Merlotti

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