Investigational cannabinoids in seizure disorders, what have we learned thus far?

Expert Opinion on Investigational Drugs
Dejana Ružić ZečevićSlobodan M Janković

Abstract

The anticonvulsant activity of cannabinoids attracted much attention in the last decade. Cannabinoids that are currently investigated with the intention of making them drugs for the treatment of epilepsy are cannabidiol, cannabidivarin, Δ9-tetrahydrocannabivarin, and Δ9-tetrahydrocannabinolic acid. In this review, the authors look at the results of preclinical and clinical studies with investigational cannabinoids. Relevant literature was searched for in MEDLINE, SCOPUS, EBSCO, GOOGLE SCHOLAR, and SCINDEX databases. Preclinical studies confirmed anticonvulsant activity of cannabidiol and cannabidivarin in a variety of epilepsy models. While the results of clinical trials with cannabidivarin are still awaited, cannabidiol showed clear therapeutic benefit and good safety in patients with therapy-resistant seizures associated with Dravet syndrome and in patients with Lennox-Gastaut syndrome who have drop seizures. However, the full therapeutic potential of cannabinoids in treatment-resistant epilepsy needs to be investigated in the near future.

References

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Citations

Sep 27, 2018·Expert Opinion on Emerging Drugs·Marco Mula
Nov 9, 2018·Expert Opinion on Investigational Drugs·Marco GrecoMaria Laura Iezzi
Dec 14, 2019·Nature Reviews. Neurology·Luigia CristinoVincenzo Di Marzo

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