Investigational drug therapies in phase I and phase II clinical trials for alcohol use disorders

Expert Opinion on Investigational Drugs
Leigh C Walker, Andrew J Lawrence

Abstract

Alcohol use disorder (AUD) is a complex psychiatric condition characterized by craving, compulsive seeking, loss of control of alcohol consumption as well as the emergence of negative emotional states during withdrawal. Despite the large socioeconomic burden of AUD, therapeutic treatment options lag behind. This review covers pharmacotherapies currently in phase I/II clinical trials for the treatment of AUDs listed on clinicaltrials.gov. We discuss drug therapies that modulate monoamine, GABA/Glutamate, neuropeptide and neuroimmune systems. We examine in depth preclinical and clinical evidence of a select range of these compounds and consider their utility in treating AUDs. Current therapeutic options to treat AUD are inadequate at a population level. Currently there are 30 different compounds and one compound combination in phase I/II clinical trials for AUD. These compounds target various aspects of neurotransmitter signaling, neuroimmune modulation, and alcohol metabolism. Almost 75% of these compounds under trial are Food and Drug Administration (FDA) approved for other indications, which may save time and costs in treatment development. Further, development of therapeutics focused on genetic biomarkers and behavioral scree...Continue Reading

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Citations

Jun 5, 2019·Expert Opinion on Drug Metabolism & Toxicology·Emily E Hartwell, Henry R Kranzler
May 9, 2019·The European Journal of Neuroscience·Leigh C WalkerAndrew J Lawrence
Jul 2, 2020·British Journal of Pharmacology·Valentina VengelieneJinhyuk Kim

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Alcohol Use Disorder

Alcohol use disorder involves a pattern of alcohol consumption that includes compulsive use and a loss of control over intake of alcohol. The impact on physical health, socioeconomic factors, and psychiatric health is profound. Find the latest research on alcohol use disorder here.

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