Investigational drugs targeting prostaglandin receptors for the treatment of glaucoma

Expert Opinion on Investigational Drugs
Artemis Matsou, Eleftherios Anastasopoulos

Abstract

Prostaglandin F2α analogs were the first prostaglandin agonists introduced for glaucoma treatment. Thanks to their efficacy and favorable tolerability they set a high bar in competition, with a resultant paucity in new hypotensive drug development for many years. However, the scientific community has shown recently a new interest in exploring new options for glaucoma treatment, generating a remarkable incentive in the marketplace for new drugs. This article reviews agents targeting prostaglandin receptors that are currently being investigated for glaucoma treatment. We searched published literature for agonists targeting all subtypes of prostaglandin receptors found in ocular tissues. EP and FP receptor agonists are currently in the spotlight of clinical research, while less attention is paid in DP receptor agonists. Prostaglandin analogs, targeting different and combinations of receptor subtypes and compounds that exhibit additivity to commonly prescribed medications seem to be highly promising options. New treatments need to be safe, more effective, superior to existing therapies, tolerable and cost-effective. New generation compounds with multiple mechanisms of action or multiagent formulations are vigorously being investiga...Continue Reading

References

Nov 1, 1975·The British Journal of Ophthalmology·W S WilsonJ L Jay
Jan 1, 1991·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M NakajimaO Hayaishi
Jun 1, 1988·The British Journal of Ophthalmology·Y GohO Hayaishi
Feb 1, 1997·Survey of Ophthalmology·D F WoodwardA Ocklind
Jun 10, 2000·Current Opinion in Ophthalmology·U SchachtschabelR N Weinreb
Jul 9, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Warren J Scherer
Sep 3, 2002·Survey of Ophthalmology·Kensaku Miyake, Nobuhiro Ibaraki
Mar 16, 2004·Survey of Ophthalmology·Achim H-P Krauss, David F Woodward
May 26, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Carol B TorisMarsha A McLaughlin
Aug 29, 2006·Investigative Ophthalmology & Visual Science·Siv F E NilssonDavid F Woodward
Nov 30, 2007·American Journal of Ophthalmology·Fotis TopouzisM Roy Wilson
Dec 17, 2008·Survey of Ophthalmology·Carol B TorisPaul L Kaufman
Feb 24, 2009·Investigative Ophthalmology & Visual Science·David F WoodwardAchim H-P Krauss
Dec 22, 2010·Indian Journal of Ophthalmology·Kuldev Singh, Anurag Shrivastava
Jan 20, 2011·Investigative Ophthalmology & Visual Science·Lindsay H MillardW Daniel Stamer
Feb 5, 2011·The Open Ophthalmology Journal·Manik GoelSanjoy K Bhattacharya
Oct 1, 2011·Seminars in Ophthalmology·Michael B Horsley, Teresa C Chen
Jun 8, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Philippe DaullJean-Sébastien Garrigue
Dec 12, 2012·Survey of Ophthalmology·Luciano QuarantaIvano Riva
Nov 28, 2013·Journal of Medicinal Chemistry·Thota Ganesh
Dec 24, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Nelson S Winkler, Michael P Fautsch
Apr 12, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Gina M YanochkoBart A Jessen
Aug 26, 2014·American Journal of Ophthalmology·Yahya ShaikhAnne L Coleman
Mar 20, 2015·Investigative Ophthalmology & Visual Science·Shinsaku YamaneKazuhito Kawabata
Apr 14, 2016·Ophthalmic Genetics·Lance P Doucette, Michael A Walter
Jul 28, 2016·American Journal of Ophthalmology·John H K LiuRobert N Weinreb
Aug 11, 2016·Drug Discovery Today·Tijana MarkovičIrena Mlinarič-Raščan

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Citations

Jan 15, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yasuko YamamotoNaveed K Shams
May 16, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yoshihiko EsakiNaveed K Shams
Nov 10, 2020·Veterinary Ophthalmology·Paul E Miller, Joshua Seth Eaton

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