Investigational Therapies for Primary Hyperoxaluria.

Bioconjugate Chemistry
Anna KletzmayrJean-Christophe Leroux

Abstract

Recent years have brought exciting new insights in the field of primary hyperoxaluria (PH), both on a basic research level as well as through the progress of novel therapeutics in clinical development. To date, very few supportive measures are available for patients suffering from PH, which, together with the severity of the disorder, make disease management challenging. Basic and clinical research and development efforts range from correcting the underlying gene mutations, preventing calcium oxalate crystal-induced kidney damage, to the administration of probiotics favoring the intestinal secretion of excess oxalate. In this review, current advances in the development of those strategies are presented and discussed.

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Citations

Sep 6, 2020·Nutrients·Matteo BargagliPietro Manuel Ferraro
Jan 30, 2021·Biochemical Pharmacology·M May ZhangXiao-Bo Zhong
Jan 31, 2021·Journal of Personalized Medicine·Maria Dolores Moya-GarzonMonica Diaz-Gavilan
Dec 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manuel Hawner, Christian Ducho
Jul 11, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Prince SinghDawn S Milliner
Aug 2, 2021·Molecular Aspects of Medicine·Manish PandeyGeetanjali Chawla
Jan 6, 2022·Journal of Synchrotron Radiation·Emmanuel EstèveMatthieu Réfrégiers

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