Investigations into growth and differentiation in the cartilage of the condylar process in the domestic pig. A quantitative study of endochondral cartilage growth and cell distribution

Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie
Knut LeidholdFriedrich Keller

Abstract

The aim of this study was to examine the extent to which the ratio of the endochondral growth components cell volume increase to matrix production was subject to age-dependent and animal-specific changes per cell in the condylar cartilage of the domestic pig. In addition, it was to be investigated whether the cell distribution in the condylar cartilage and thus the tissue differentiation changes as one aspect of the aging process and whether the differentiation differs from that of primary hyaline cartilage. The tissue specimens available were hematoxylin/eosin-stained section series from the cartilage of the condylar process of six domestic pigs (0-24 months) of the genus Suis scrofa. Using a special squared measuring grid in the optical path of a microscope, the following histomorphometric primary parameters were ascertained in the cartilage zones under investigation: the average section area of the cartilage cells and the number of cut cells per unit area. From these figures, the cell volume and the extracellular matrix volume per cell were calculated using the stereological calculation algorithm for ellipsoids of revolution in accordance with Weibel and Gomez. Quantitative analysis of the cell distribution pattern was based...Continue Reading

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