PMID: 1212658Dec 1, 1975Paper

Investigations into the metabolism and mode of action of the colon carcinogen 1, 2-dimethylhydrazine

Cancer
E S Fiala

Abstract

Chromatographic methods have been developed which allow the separation and identification of azomethane (AM), azoxymethane (AOM), and methylazoxymethanol (MAM). These methods have been applied to the analysis of bile, urine, and the exhaled air of rats treated with the 14C--labeled colon carcinogen 1,2-dimethylhydrazine (DMH) to provide evidence that AM, AOM, and MAM are indeed metabolites of DMH. Investigations into the metabolism and mode of action of DMH and its derivatives by other workers are briefly summarized and reviewed.

References

Feb 19, 1975·Journal of Chromatography·E S Fiala, J H Weisburger
Dec 1, 1972·Toxicology and Applied Pharmacology·L W Wattenberg
Nov 1, 1973·Diseases of the Colon and Rectum·J H Weisburger
Oct 1, 1974·The American Journal of Digestive Diseases·E L Wynder, B S Reddy
Oct 1, 1974·The American Journal of Digestive Diseases·L W Wattenberg
Nov 1, 1973·British Journal of Cancer·R Schoental
Sep 1, 1974·Cancer·M J Hill
Jul 1, 1971·Cancer·D P Burkitt
Jun 1, 1967·Die Naturwissenschaften·H DruckreyS Ivankovic
May 1, 1965·Archives of Biochemistry and Biophysics·A KOBAYASHI, H MATSUMOTO

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Citations

Jan 1, 1984·Nutrition and Cancer·S WolterN Frank
Jan 17, 2002·Archives of Pharmacal Research·D H Kim, Y H Jin
Jan 1, 1977·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·B WernerH Mitschke
Oct 22, 2008·Human Gene Therapy·Federica MoriLuigi Aurisicchio
May 23, 2020·Toxicology Research·Karthikkumar VenkatachalamRajasekar Ponnaiyan
Jan 1, 1989·Teratogenesis, Carcinogenesis, and Mutagenesis·R E Neft, M K Conner
Apr 29, 1998·Diseases of the Colon and Rectum·A Banerjee, P Quirke
Apr 10, 2013·Inflammatory Bowel Diseases·Klara KlimesovaHelena Tlaskalova-Hogenova
Feb 6, 2017·Journal of Oleo Science·Shinji YamashitaMikio Kinoshita
Apr 22, 1977·Langenbecks Archiv für Chirurgie·B WernerH Mitschke
Jan 1, 1994·Drug Metabolism Reviews·A H Hofstra
Aug 31, 2002·Journal of Gastroenterology and Hepatology·Isao OkayasuToshifumi Ohkusa
Oct 25, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Neamt H A OsmanEsraa S A Ahmed
Aug 15, 1978·International Journal of Cancer. Journal International Du Cancer·G BrambillaL Robbiano
Jan 1, 1985·Pharmacology & Therapeutics·A DippleE K Weisburger
Dec 1, 1982·Chemico-biological Interactions·S Wolter, N Frank
Mar 1, 1986·Mutation Research·L C Boffa, C Bolognesi
Oct 18, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yvonne E M DommelsBen van Ommen
Mar 1, 1977·Cancer Letters·K M PozharisskiR M Balansky
Aug 12, 2021·Chemical Research in Toxicology·Peter S Spencer, Glen E Kisby
Feb 8, 2014·Chemical Research in Toxicology·Birandra K SinhaRonald P Mason

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