Investigations into the toxicology of spirolides, a group of marine phycotoxins.

Toxins
Rex MundayShawna L MacKinnon

Abstract

Spirolides are marine phycotoxins produced by the dinoflagellates Alexandrium ostenfeldii and A. peruvianum. Here we report that 13-desmethyl spirolide C shows little cytotoxicity when incubated with various cultured mammalian cell lines. When administered to mice by intraperitoneal (ip) injection, however, this substance was highly toxic, with an LD(50) value of 6.9 µg/kg body weight (BW), showing that such in vitro cytotoxicity tests are not appropriate for predicting the in vivo toxicity of this toxin. Four other spirolides, A, B, C, and 20-methyl spirolide G, were also toxic to mice by ip injection, with LD(50) values of 37, 99, 8.0 and 8.0 µg/kg BW respectively. However, the acute toxicities of these compounds were lower by at least an order of magnitude when administration by gavage and their toxic effects were further diminished when administered with food. These results have implications for future studies of the toxicology of these marine toxins and the risk assessment of human exposure.

References

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Citations

Nov 15, 2013·Toxins·Rex Munday, John Reeve
May 7, 2014·Marine Drugs·Clara GrossoPaula B Andrade
Feb 1, 2018·Marine Drugs·Jimmy AlarcanValérie Fessard
Jan 17, 2014·Natural Product Reports·Ryuichi Sakai, Geoffrey T Swanson
Jun 14, 2014·Chemistry : a European Journal·Jessica Labarre-LainéYannick Landais
Jun 13, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Romulo AráozDenis Servent
Jul 6, 2013·Toxicon : Official Journal of the International Society on Toxinology·Laura P RodríguezLuis M Botana
Jun 19, 2021·Food Chemistry·Monali MukherjeePraveena Bhatt
Sep 5, 2013·Organic Letters·Jessica Labarre-LainéYannick Landais
Jun 5, 2012·Chemical Research in Toxicology·Luis M Botana

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Methods Mentioned

BETA
NMR

Software Mentioned

AOT
ChemStation

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