Investigations of 2 cases of diphtheria-like illness due to toxigenic Corynebacterium ulcerans

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Tejpratap TiwariM Wharton

Abstract

We present 2 case reports in the United States and investigations of diphtheria-like illness caused by toxigenic Corynebacterium ulcerans. A fatal case occurred in a 75-year-old male Washington resident who was treated with clindamycin but did not receive equine diphtheria antitoxin. A second, nonfatal case occurred in a 66-year-old female Tennessee resident who received erythromycin and diphtheria antitoxin. Both case patients and close human and animal contacts were investigated by their respective state health departments. C. ulcerans isolated from the patient who died was resistant to erythromycin and clindamycin. For both isolates, conventional polymerase chain reaction results were positive for A and B subunits of diphtheria toxin gene tox, and modified Elek tests confirmed toxin production. The source of infection remained undetermined for both cases. Neither patient was up-to-date with diphtheria toxoid vaccination. These case reports highlight the importance of early treatment with diphtheria antitoxin, the selection of effective antimicrobial agents, and prevention through up-to-date vaccination.

References

Sep 1, 1992·The Journal of Laryngology and Otology·J P de CarpentierW Y Nassar
Oct 1, 1985·Southern Medical Journal·S M Siegel, C A Haile
Feb 7, 1970·Lancet·R W Fakes, M Downham
Jul 8, 1967·The Veterinary Record·T M HiggsF K Neave
Nov 1, 1984·The Journal of Infection·A D BostockD C Smith
Apr 1, 1984·The Journal of Hygiene·R J Hart
Apr 15, 1994·Deutsche medizinische Wochenschrift·M H HustR H Seuffer
Feb 1, 1997·Journal of Clinical Microbiology·K H EnglerA Efstratiou
Jul 1, 1997·Journal of Clinical Microbiology·H Nakao, T Popovic
Mar 13, 1999·Journal of Clinical Microbiology·J HommezF Haesebrouck
Sep 25, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J WagnerH Hahn
Jul 18, 2002·Infection·D KaufmannC Ruegg
Jul 26, 2002·International Journal of Medical Microbiology : IJMM·Nele WellinghausenJochen Rentschler
Nov 28, 2002·Journal of Clinical Microbiology·Elizabeth A MothershedTanja Popovic
Jun 5, 2003·Emerging Infectious Diseases·Akio HatanakaMotohide Takahashi
Nov 8, 2003·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·C KellyUNKNOWN European Diphtheria Surveillance Network
Jan 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andreas SingJürgen Heesemann
Feb 8, 2005·Journal of Clinical Microbiology·Marie-Frédérique LartiguePatrice Nordmann
Mar 25, 2005·The Veterinary Record·W E MorrisA L Cipolla
Jan 24, 2006·La Revue de médecine interne·L AaronY Guimard
Sep 13, 2006·Nutrition and Cancer·Mark MessinaAnna H Wu

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Citations

Jun 21, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Regina SchuheggerAndreas Sing
Jan 9, 2010·Vector Borne and Zoonotic Diseases·Alexandre A S O DiasAna L Mattos-Guaraldi
Mar 27, 2010·Journal of Veterinary Internal Medicine·J E SykesB A Byrne
Jul 9, 2010·Clinical and Vaccine Immunology : CVI·Paolo Di GiovineChristina von Hunolstein
Oct 16, 2009·Journal of Clinical Microbiology·S E NealUNKNOWN International Diphtheria Reference Laboratories
Jun 14, 2008·Journal of Clinical Microbiology·Regina SchuheggerAndreas Sing
Oct 27, 2011·Tropical Medicine and Health·Nimfa PutongEfren M Dimaano
Sep 16, 2009·Emerging Infectious Diseases·Regina SchuheggerAndreas Sing
Feb 7, 2012·Emerging Infectious Diseases·Karen S WagnerUNKNOWN Diphtheria Surveillance Network
May 10, 2012·Future Microbiology·Katherina Zakikhany, Androulla Efstratiou
Aug 26, 2011·The Journal of Infection·Qi ZhangZhujun Shao
Nov 28, 2014·Genome Announcements·Marcus Vinicius Canário VianaLuis Carlos Guimarães
Jul 12, 2011·Veterinary Microbiology·A A S O DiasA L Mattos-Guaraldi
Apr 28, 2009·Vaccine·Isabelle BonmarinDaniel Levy-Bruhl
Aug 10, 2011·Zoonoses and Public Health·M ContzenJ Rau
Sep 17, 2011·Journal of Medical Microbiology·Chihiro KatsukawaMotohide Takahashi
Dec 12, 2012·Journal of Medical Microbiology·Takaaki UrakawaShinichi Goto
Jul 21, 2015·The Lancet Infectious Diseases·Luke S P MooreShiranee Sriskandan
Sep 19, 2015·Standards in Genomic Sciences·Atteyet F YassinNikos C Kyrpides
Mar 27, 2012·FEMS Immunology and Medical Microbiology·Lisa OttPaul A Hoskisson
Jun 2, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R KonradA Sing
Aug 23, 2016·Future Microbiology·Elena HackerAndreas Tauch
Sep 21, 2012·Nihon Jibiinkoka Gakkai kaiho·Tomoko KamadaKen Kitamura
Dec 6, 2019·Nature Reviews. Disease Primers·Naresh Chand SharmaThandavarayan Ramamurthy
Oct 28, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eleonora BrilloErsilia Buonomo
Nov 30, 2011·Revista de saúde pública·Alexandre Alves de Souza de Oliveira DiasAna Luíza Mattos Guaraldi
Feb 21, 2018·Emerging Infectious Diseases·Ikkoh YasudaTakeshi Tanaka
Nov 19, 2019·Communicable Diseases Intelligence·Aditi DeyPeter McIntyre
Mar 27, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Charlotte M GowerGayatri Amirthalingam
Sep 4, 2020·Veterinary Medicine International·Erdachew YitagesuChekol Demis
Apr 30, 2017·The Keio Journal of Medicine·Toru HifumiKazuo Umezawa
Apr 28, 2018·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Jennifer L LiangThomas A Clark
Aug 21, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John O OtshudiemaTejpratap S P Tiwari
Apr 4, 2021·Vaccines·Salvatore Giovanni De-SimoneFlavio Rocha da Silva
Jun 19, 2021·Frontiers in Veterinary Science·Flavia ZendriDorina Timofte

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