Investigations of micron and submicron wear features of diseased human cartilage surfaces

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
Zhongxiao PengMeiling Wang

Abstract

Osteoarthritis is a common disease. However, its causes and morphological features of diseased cartilage surfaces are not well understood. The purposes of this research were (a) to develop quantitative surface characterization techniques to study human cartilages at a micron and submicron scale and (b) to investigate distinctive changes in the surface morphologies and biomechanical properties of the cartilages in different osteoarthritis grades. Diseased cartilage samples collected from osteoarthritis patients were prepared for image acquisition using two different techniques, that is, laser scanning microscopy at a micrometer scale and atomic force microscopy at a nanometer scale. Three-dimensional, digital images of human cartilages were processed and analyzed quantitatively. This study has demonstrated that high-quality three-dimensional images of human cartilage surfaces could be obtained in a hydrated condition using laser scanning microscopy and atomic force microscopy. Based on the numerical data extracted from improved image quality and quantity, it has been found that osteoarthritis evolution can be identified by specific surface features at the micrometer scale, and these features are amplitude and functional property...Continue Reading

References

Jul 1, 1975·Clinical Orthopaedics and Related Research·R E Outerbridge, J A Dunlop
Jan 1, 1976·Journal of Biomechanics·R Y Hori, L F Mockros
May 27, 1999·Annals of the Rheumatic Diseases·D E Shepherd, B B Seedhom
Nov 17, 2001·Arthritis and Rheumatism·M HudelmaierF Eckstein
Jun 23, 2005·Osteoarthritis and Cartilage·Thomas M QuinnHans-Jörg Häuselmann
Dec 7, 2007·Journal of Biomechanics·Jeffrey M ColesStefan Zauscher
Feb 28, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ying JiangToshimasa Uemura
Feb 27, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Robert J BuckUNKNOWN A9001140 Investigators
Apr 27, 2010·Osteoarthritis and Cartilage·S M T ChanA H Reddi
Jan 1, 2009·Archives of Histology and Cytology·Raphael ImerUrs Staufer
Jun 26, 2012·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Anders JohanssonÅke Öberg
Jul 10, 2012·Micron : the International Research and Review Journal for Microscopy·Siddharth GhoshDuncan E T Shepherd

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Methods Mentioned

BETA
scanning
atomic
confocal microscopy
AFM
biopsy
imaging
imaging technique

Software Mentioned

Scanning Probe Image Processor ( SPIP ) Metrology

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