Investigations of the function of the vascular endothelium in portal hypertensive rats

Pharmacology
T CawleyJames R Docherty

Abstract

There were no differences between mesenteric arteries from sham or 14-day portal hypertensive (PH) rats in the potency of or maximum endothelium-dependent relaxations (EDR) to acetylcholine. There were no differences between sham-operated and PH rats in the effects of the combination of the nitric oxide synthase inhibitor NG-monomethyl-L-arginine (100 mumol/l) and methylene blue (10 mumol/l) in causing a significant reduction in the EDR to acetylcholine. The degree of portal-systemic shunting, as measured by 57Co-labeled microspheres, was unaffected by acute administration of NG-monomethyl-L-arginine (50 mg/kg) or methylene blue (5 mg/kg). In conclusion, nitric oxide is the main mediator of EDR in rat mesenteric artery, and no evidence was found for an increased role for endothelial-derived nitric oxide in PH rats.

Citations

Feb 6, 2003·European Journal of Pharmacology·Wenxuan YangBarry Alexander
Jan 10, 1998·British Journal of Pharmacology·R W AboudJ R Docherty
Jan 23, 1999·Journal of Autonomic Pharmacology·J McDaidJ R Docherty
Jul 8, 2008·European Journal of Pharmacology·Sotiria BexisJames R Docherty
Oct 22, 2013·European Journal of Pharmacology·Jun Liong ChinJames R Docherty
Feb 2, 2018·PloS One·Evelyn Li Min TaiIsmail Shatriah

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