May 7, 1976

Investigations of the lipase activity of a pancreatin compound (author's transl)

Medizinische Klinik
P Preisich

Abstract

In connection with the physiologic process of digestion, the requirements for an enzyme-based drug are stated. Quick release of highly active enzymes in the duodenum is a prerequisite of physiological stimulation of the pancreatic excretory function. Digestive potency is regarded as a suitable gauge for comparing of results in large-scale in vitro scanning. Our own in vitro and in vivo studies have borne out the possibility of transferring in vitro findings to the therapeutic value of this compound. As shown by our investigations, quick release of highly active enzymes in vitro is coupled with a high degree of bioavailability in Fermento duodenal. As a result, normalization or reduction of the lipid content of faeces--as a sign of therapeutic efficacy--is seen in patients with pancreatic excretory insufficiency. Statistical evaluation resulted in the following: 1 A statistically significant (p less than 0.1%) increase in lipase activity in the duodenal juice in vitro after addition of one capsule of Fermento duodenal. 2. Lipase activity in vivo after 15 minutes is significantly different from all other values. 3. A statistically significant (p less than 1%) drop in the amount and lipid content of faeces following the treatment ...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Exocrine Pancreatic Insufficiency
Enzymes, antithrombotic
Microbial Anatomical Capsule Structure
Duodenum
Duodenal Juice
Entire Duodenum
Drug Evaluation
Enzymes for Treatment of Wounds and Ulcers
Lipase Activity
Excretory Function

About this Paper

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

LRRK2 & Immunity During Infection

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Meningococcal Myelitis

Meningococcal myelitis is characterized by inflammation and myelin damage to the meninges and spinal cord. Discover the latest research on meningococcal myelitis here.

Alzheimer's Disease: MS4A

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.