May 7, 1976

Investigations of the lipase activity of a pancreatin compound (author's transl)

Medizinische Klinik
P Preisich


In connection with the physiologic process of digestion, the requirements for an enzyme-based drug are stated. Quick release of highly active enzymes in the duodenum is a prerequisite of physiological stimulation of the pancreatic excretory function. Digestive potency is regarded as a suitable gauge for comparing of results in large-scale in vitro scanning. Our own in vitro and in vivo studies have borne out the possibility of transferring in vitro findings to the therapeutic value of this compound. As shown by our investigations, quick release of highly active enzymes in vitro is coupled with a high degree of bioavailability in Fermento duodenal. As a result, normalization or reduction of the lipid content of faeces--as a sign of therapeutic efficacy--is seen in patients with pancreatic excretory insufficiency. Statistical evaluation resulted in the following: 1 A statistically significant (p less than 0.1%) increase in lipase activity in the duodenal juice in vitro after addition of one capsule of Fermento duodenal. 2. Lipase activity in vivo after 15 minutes is significantly different from all other values. 3. A statistically significant (p less than 1%) drop in the amount and lipid content of faeces following the treatment ...Continue Reading

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Mentioned in this Paper

Exocrine Pancreatic Insufficiency
Enzymes, antithrombotic
Microbial Anatomical Capsule Structure
Duodenal Juice
Entire Duodenum
Drug Evaluation
Enzymes for Treatment of Wounds and Ulcers
Lipase Activity
Excretory Function

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