Investigations of the mode of action of a new antidysrhythmic drug, Kö 1173

British Journal of Pharmacology
B N Singh, E M Vaughan Williams


1. Kö 1173, 1-(2',6'-dimethyl-phenoxy)-2-amino-propane, was equal to lignocaine in potency as a local anaesthetic on stripped frog sciatic nerve at pH 7.5.2. In anaesthetized guinea-pigs in which ventricular fibrillation had been produced by an intravenous infusion of ouabain, intravenous administration of Kö 1173 caused reversion to sinus rhythm in ten out of ten animals. The mean dose of Kö 1173 required was 3.3 mg (15.3 mumol)/kg. When the ouabain infusion was continued, ventricular fibrillation did not recur, and the lethal dose of ouabain was greater than in controls.3. Pretreatment with Kö 1173, however, did not influence the toxicity of ouabain infusion, implying great brevity of action.4. Kö 1173 given intravenously caused a bradycardia which was maximal in 2-3 min, and which did not last more than 5 minutes.5. Kö 1173 reduced the maximum driven frequency of isolated rabbit atria, raised electrical threshold, slowed conduction velocity and depressed contractions.6. Kö 1173 reduced the maximum rate of depolarization of intracellularly recorded rabbit atrial and ventricular potentials, but did not affect the resting potential or the duration of the action potential.


Nov 1, 1970·American Heart Journal·L S Dreifus, Y Watanabe
Feb 1, 1968·Circulation Research·J T BiggerB F Hoffman
Jun 1, 1969·British Journal of Pharmacology·A N DohadwallaE M Vaughan Williams
Sep 1, 1958·British Journal of Pharmacology and Chemotherapy·E M VAUGHAN WILLIAMS
Mar 1, 1962·The Journal of Physiology·L Szekeres, E M Williams

❮ Previous
Next ❯


May 1, 1990·Clinical Cardiology·A S ManolisN A Estes
Jun 19, 1978·European Journal of Clinical Pharmacology·G Koch, B Lindström
Apr 3, 2010·Journal of Computer-aided Molecular Design·Rayomand J UnwallaChristine Humblet
Dec 1, 1973·European Journal of Pharmacology·V KecskemètiJ Knoll
Aug 27, 1981·European Journal of Pharmacology·K R Courtney
Mar 11, 1986·European Journal of Pharmacology·O IgawaH Mashiba
Jan 1, 1975·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·E M Vaughan Williams
Oct 1, 1985·Journal of the American College of Cardiology·J C RutledgeE A Amsterdam
Mar 1, 1994·British Journal of Pharmacology·Y DohiK Sato
Nov 1, 1977·Journal of Neurology, Neurosurgery, and Psychiatry·P J Selby, M V Driver
Dec 1, 1990·The International Journal of Neuroscience·G I Awerbuch, R Sandyk
Apr 1, 1976·Journal of Pharmaceutical Sciences·P H Morgan, I W Mathison
May 1, 1984·American Heart Journal·R L WoosleyD Roden
Jan 1, 1980·Progress in Cardiovascular Diseases·B N SinghC Y Chew
Nov 1, 1977·Progress in Cardiovascular Diseases·D C HarrisonR A Winkle
Oct 27, 2011·Neuroscience Letters·Kuo-Lun HuangMou-Yung Yeh
Mar 1, 1974·American Heart Journal·B N Singh, O Hauswirth
Apr 1, 1983·American Heart Journal·V SantinelliM Condorelli
Dec 1, 1988·Chest·D InoueM Nakagawa
Feb 1, 1979·British Heart Journal·N P CampbellJ F Pantridge
Jul 1, 1978·British Heart Journal·N P CampbellA A Adgey
Feb 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Takenori YaoMinoru Horie
Oct 18, 1980·British Medical Journal·S D SlaterJ G McCall
Jan 1, 1987·The New England Journal of Medicine·R W Campbell
Mar 1, 1973·British Journal of Pharmacology·F E CrawleyM Swash
Apr 1, 1986·Drug Intelligence & Clinical Pharmacy·B J Schrader, J L Bauman
Oct 1, 1977·Scandinavian Journal of Clinical and Laboratory Investigation·R W HarperE Varnauskas
Jan 1, 1978·Acta Medica Scandinavica. Supplementum·S B Olsson, R W Harper
Dec 1, 1975·Epilepsia·J J CereghinoL D Smith

❮ Previous
Next ❯

Related Concepts

Related Feeds


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.


Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.