1. Kö 1173, 1-(2',6'-dimethyl-phenoxy)-2-amino-propane, was equal to lignocaine in potency as a local anaesthetic on stripped frog sciatic nerve at pH 7.5.2. In anaesthetized guinea-pigs in which ventricular fibrillation had been produced by an intravenous infusion of ouabain, intravenous administration of Kö 1173 caused reversion to sinus rhythm in ten out of ten animals. The mean dose of Kö 1173 required was 3.3 mg (15.3 mumol)/kg. When the ouabain infusion was continued, ventricular fibrillation did not recur, and the lethal dose of ouabain was greater than in controls.3. Pretreatment with Kö 1173, however, did not influence the toxicity of ouabain infusion, implying great brevity of action.4. Kö 1173 given intravenously caused a bradycardia which was maximal in 2-3 min, and which did not last more than 5 minutes.5. Kö 1173 reduced the maximum driven frequency of isolated rabbit atria, raised electrical threshold, slowed conduction velocity and depressed contractions.6. Kö 1173 reduced the maximum rate of depolarization of intracellularly recorded rabbit atrial and ventricular potentials, but did not affect the resting potential or the duration of the action potential.
Effect of altering potassium concentration on the action of lidocaine and diphenylhydantoin on rabbit atrial and ventricular muscle
Relationship between the plasma level of diphenylhydantoin sodium and its cardiac antiarrhythmic effects
The mode of action of quinidine on isolated rabbit atria interpreted from intracellular potential records
The effect of changes in extracellular potassium concentration on the intracellular potentials of isolated rabbit atria
Determination of the enantiomeric composition of mexiletine and its four hydroxylated metabolites in urine by enantioselective capillary gas chromatography
Effects of mexiletine on transmembrane action potentials as affected by external potassium concentration and by rate of stimulation in guinea-pig papillary muscles
An unusual cause of apparent epilepsy: ECG and EEG findings in a case of Jervell Lange-Neilson syndrome
Lack of effectiveness of oral mexiletine in patients with drug-refractory paroxysmal sustained ventricular tachycardia. A study utilizing programmed stimulation
Investigation of the antifibrillatory activity of some anticonvulsant gamma-aminobutyric acid-transaminase inhibitors in the rabbit isolated heart: comparison with phenytoin and mexiletine
Refractory gradient is responsible for the increase in ventricular vulnerability under sodium channel blockade
Atenolol, but not mexiletine, protects against stimulus-induced ventricular tachycardia in a chronic canine model
Mexiletine--findings in animal experiments on its antiarrhythmic and electrophysiological effects in the heart (author's transl)
The effects on cardiac muscle and nerve of a fluorinated decahydroquinoline derivative, L7810, rapidly absorbed after oral administration
Investigations to characterize a new anti-arrhythmic drug, ORG 6001 including a simple test for calcium antagonism
Evaluation of antagonism of aconitine-induced dysrhythmias in mice as a method of detecting and assessing antidysrhythmic activity
Ontogenesis of the multiple forms of choline acetyltransferase: uptake and acetylation of choline in rat brain [proceedings
The antifibrillatory potency of aprindine, mexiletine, tocainide and lignocaine compared on Langendorff-perfused hearts of rabbits and guinea-pigs
Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.
Cardiac Conduction System
The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.
Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.