Investigations on benzyltoluenes. I. Induction of microsomal cytochrome P-450 and UDP-glucuronosyltransferase by tetrachlorobenzyltoluenes and by the condensate

Toxicology Letters
L von MeyerinckH F Benthe

Abstract

Tetrachlorobenzyltoluene (TCBT) (Ugilec 141) was investigated in induction experiments in male and female Wistar rats with long-term (50, 100 and 300 mg/kg p.o. daily for 28 days) and short-term administration (300 mg/kg once and 100 mg/kg daily for 4 days). The increase in total cytochrome P-450 did not exceed the factor of 1.9 compared to controls, while benzphetamine N-demethylase rose up to 3.5-fold the levels measured in controls, with very low induction of benzo(a)pyrene hydroxylase or ethoxyresorufin O-deethylase. Parallel investigations of UDP-glucuronosyltransferase showed induction of testosterone glucuronidation (1.7-fold). Administration (300 mg/kg body wt. once) of a pyrolysate of TCBT resulted in a marked increase in cytochrome P-450c dependent reactions (benzo(a)pyrene hydroxylase, ethoxyresorufin O-deethylase).

References

Jan 1, 1978·Methods in Enzymology·R A ProughR T Mayer
Jan 1, 1989·The Prostate·F DonnH Klosterhalfen
Jan 1, 1987·Bulletin of Environmental Contamination and Toxicology·P Larsson
Oct 1, 1988·Bulletin of Environmental Contamination and Toxicology·V LeoniA R Giuliani
Jun 1, 1973·Analytical Biochemistry·W DehnenJ Roos

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Citations

Mar 20, 1992·Journal of Chromatography·V Lang

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