PMID: 3771621Jan 1, 1986Paper

Investigations on metabolism, genotoxic effects and carcinogenicity of 2,2'-dichlorodiethylether

Journal of Cancer Research and Clinical Oncology
K NorpothC Witting

Abstract

Either 40 mumole or 160 mumole 2,2'-DDE was injected into male Wistar rats and the metabolites, TdGA and HEMA, were determined in the 24-h urine specimens. Comparative investigations were carried out giving equimolar amounts of chloroethanol and 2-chloroacetaldehyde diethyl acetal. In a further step, inhalation experiments were performed to determine urinary excretion of the two metabolites after an 8-h exposure of male Wistar rats to 10, 50, 100, and 500 ppm 2,2'-DDE and to 50, 200, und 1,000 ppm vinyl chloride. A long-term study was conducted to investigate the possible carcinogenicity of 2,2'-DDE in male and female Sprague-Dawley rats following s.c. injections of 4.36 mumole and 13.1 mumole 2,2'-DDE in DMSO per week. The evaluation of tumor development in treated groups and controls were based on macroscopic inspection and histological examinations of the suspect organs and tissues. Analysis of the metabolites showed that HEMA excretion was much lower than the excretion of TdGA following the uptake of 2,2'-DDE, 2-chloroethanol and 2-chloroacetaldehyde diethyl acetal. Contrary to these, vinyl chloride uptake resulted in a higher urinary excretion of HEMA than TdGA. There was no appreciable increase in the number of tumors det...Continue Reading

References

Jan 1, 1979·Toxicology and Applied Pharmacology·R D LinggR G Tardiff
May 1, 1976·Toxicology and Applied Pharmacology·P G WatanabeP J Gehring
Mar 7, 1947·Science·C AuerbachJ G Carr

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Citations

Jan 1, 1988·Journal of Cancer Research and Clinical Oncology·K NorpothC Witting
Nov 1, 1987·Bulletin of Environmental Contamination and Toxicology·B S Kaphalia, G A Ansari

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