Investigations on the mode of action of a new antihypertensive drug, urapidil, in the isolated rat vas deferens

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Investigations on the mode of action of a new antihypertensive drug, urapidil, in the isolated rat vas deferens

Abstract

References

Relative pre- and postsynaptic potencies of alpha-adrenoceptor agonists in the rabbit pulmonary artery

Effects of alpha-adrenoceptor agonists and antagonists on pre- and postsynaptically located alpha-adrenoceptors

Centrally induced reduction in sympathetic tone-a postsynaptic alpha-adrenoceptor-stimulating action of imidazolines

Pharmacological characterisation of the presynaptic alpha-adrenoceptor in the rat vas deferens

Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors

Presynaptic receptor systems on the noradrenergic neurones of rat brain

Prazosin: differential affinities for two populations of alpha-noradrenergic receptor binding sites

Pre- and postsynaptic alpha-adrenoceptor antagonism by indoramin in isolated tissues of the rat

A comparative study on the pre- and post-synaptic alpha blocking activity of a series of benzodioxanes

The central action of antihypertensive drugs, mediated via central alpha-receptors

Effect of duration and frequency of stimulation on the presynaptic inhibition by alpha-adrenoceptor stimulation of the adrenergic transmission

Uptake mechanisms for neurotransmitter amines

Influence of cocaine and phenoxybenzamine on noradrenaline uptake and release

Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart

Presynaptic regulation of catecholamine release

Some quantitative uses of drug antagonists

pA, a new scale for the measurement of drug antagonism

Citations

Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites

Pharmacological characterisation of pre- and postsynaptic alpha-adrenoceptors in dog saphenous vein

Comparison of the antihypertensive effect of urapidil and metoprolol in hypertension

Antihypertensive effects of urapidil and clonidine: a double-blind cross-over study

High and low (Gpp(NH)p-sensitive) affinity sites for beta 2-adrenergic blockers as antagonists of isoproterenol in the field-stimulated rat vas deferens

Interaction of the antihypertensive drug urapidil with cardiac beta-adrenoceptors in vitro

Effects of urapidil, clonidine, prazosin and propranolol on autonomic nerve activity, blood pressure and heart rate in anaesthetized rats and cats

Effect of urapidil on beta-adrenoceptors of rat atria

Beta 1-adrenoceptor antagonism by urapidil prior to and after the alpha 2-antagonist rauwolscine in anesthetized dogs

Vasodilatation elicited by 5-HT1A receptor agonists in constant-pressure-perfused rat kidney is mediated by blockade of alpha 1A-adrenoceptors

Histamine H1 receptors mediate vasodilation in guinea-pig ileum resistance vessels: characterization with computer-assisted videomicroscopy and new selective agonists

Biogenic amines and morphine responses in the rat vas deferens

Stereoselective binding of niguldipine enantiomers to alpha 1A-adrenoceptors labeled with [3H]5-methyl-urapidil

Pharmacological activities of the antihypertensive drug urapidil in the rat

Systemic and regional hemodynamic effects of acute and prolonged treatment with urapidil or prazosin in normotensive and spontaneously hypertensive rats

Pharmacologic profile of urapidil

Immediate hemodynamic changes produced by urapidil in normotensive and spontaneously hypertensive rats

Present concepts and perspectives of antihypertensive therapy

Propranolol, clonidine, urapidil and trazodone infusion in essential tremor: a double-blind crossover trial

Deviating central hypotensive activity of urapidil in the cat

Influence of urapidil on alpha- and beta-adrenoreceptors in pithed rats

Selectivities of some agonists acting at alpha 1- and alpha 2-adrenoreceptors in the rat vas deferens

Pharmacokinetics and pharmacodynamics of urapidil in severe hypertension

Adrenergic activity and aldosterone regulation: no evidence for an alpha-1 adrenoceptor-mediated influence in normal subjects

Effect of urapidil, clonidine, and prazosin on sympathetic tone in conscious rats

Relationship of alpha receptor types to hypotension and renal vasodilation caused by alpha blockers in conscious dogs

Presynaptic alpha-adrenoreceptors; in vitro methods and preparations utilised in the evaluation of agonists and antagonists

Characterization of the adrenoreceptor activities of isoprenaline in the field stimulated rat vas deferens: selective supersensitivity to beta 2-mediated responses following reserpine treatment

Characterization of postsynaptic alpha-adrenoceptors in rat aortic strips and portal veins

Facilitation by clonidine of purine release induced by high KCl from the rabbit pulmonary artery

The place of alpha-adrenoceptor and beta-adrenoceptor blockade in the treatment of hypertension

The use of neurally released agonist in the measurement of antagonism at alpha-adrenoceptors

Related Concepts

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Interaction of the antihypertensive drug urapidil with cardiac beta-adrenoceptors in vitro

Immediate hemodynamic changes produced by urapidil in normotensive and spontaneously hypertensive rats

Relationship of alpha receptor types to hypotension and renal vasodilation caused by alpha blockers in conscious dogs

Effect of urapidil on beta-adrenoceptors of rat atria

Regional histaminergic potencies in rabbit systemic circulation