Investigations on the protective role of passively transferred antibodies against avian metapneumovirus infection in turkeys

Avian Pathology : Journal of the W.V.P.A
Dennis Rubbenstroth, Silke Rautenschlein

Abstract

The avian metapneumovirus (aMPV) is the causative agent of an acute respiratory disease in turkeys, which causes considerable economic losses to the poultry industry. Currently attenuated live and inactivated vaccines are widely used to control the disease, but vaccine breaks are frequently observed. For improvement of current vaccination strategies it is necessary to gain enhanced knowledge of the immune mechanisms against aMPV infection. Field observations suggest that vaccine-induced aMPV-specific antibodies are not indicative for protection. In the present study we investigated the role of antibodies in protection of turkeys against aMPV. In two experiments, commercial turkey poults received aMPV-specific antibodies by intravenous injection. The antibody transfer resulted in increased antibody levels in the sera. Virus-specific antibodies were also detected on mucosal surfaces such as the trachea, conjunctivae and gall bladder. Turkeys were subsequently challenged with a virulent aMPV subtype A strain. Development of clinical signs, virus detection by polymerase chain reaction and histopathological changes of tracheal mucosa in challenged turkeys with and without passively transferred antibodies were comparable with each ot...Continue Reading

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Citations

Apr 20, 2011·Avian Diseases·Jorge Luis ChacónAntonio J Piantino Ferreira
Dec 25, 2010·Veterinary Immunology and Immunopathology·Silke RautenschleinChristine Haase
Jan 2, 2010·Developmental and Comparative Immunology·Dennis RubbenstrothSilke Rautenschlein
May 18, 2016·Veterinary Immunology and Immunopathology·Chris J Hedegaard, Peter M H Heegaard
Nov 23, 2017·Avian Pathology : Journal of the W.V.P.A·Rebecca KnabArne Jung

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
PCR
PCRs
electrophoresis
light microscopy

Software Mentioned

Statistix

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