journal cover

Investigations to characterize a new anti-arrhythmic drug, ORG 6001 including a simple test for calcium antagonism

British Journal of Pharmacology

Jun 1, 1976

L A SalakoJ H Wittig

Abstract

1 The compound Org 6001 (3alpha-amino-2beta-hydroxy-5alpha-androstan-17-one hydrochloride) was found in recent experiments to exhibit anti-arrhythmic activity. Evidence is presented in this paper concerning its mode of action. 2 Org 6001 was 1.8 times more potent than procaine as a loca...read more

Mentioned in this Paper

Myocardial Contraction
Calcium [EPC]
Structure of Sciatic Nerve
PCP2 protein, human
Calcium
Left Ventricular Structure
Resting Potentials
Potassium
Action Potentials
Anti-Arrhythmia Agents
Paper Details
References
  • References16
  • Citations14
12
  • References16
  • Citations14
12

Feeds With Similar Papers

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

© 2020 Meta ULC. All rights reserved

Investigations to characterize a new anti-arrhythmic drug, ORG 6001 including a simple test for calcium antagonism

British Journal of Pharmacology

Jun 1, 1976

L A SalakoJ H Wittig

PMID: 7336

DOI: 10.1111/j.1476-5381.1976.tb07475.x

Abstract

1 The compound Org 6001 (3alpha-amino-2beta-hydroxy-5alpha-androstan-17-one hydrochloride) was found in recent experiments to exhibit anti-arrhythmic activity. Evidence is presented in this paper concerning its mode of action. 2 Org 6001 was 1.8 times more potent than procaine as a loca...read more

Mentioned in this Paper

Myocardial Contraction
Calcium [EPC]
Structure of Sciatic Nerve
PCP2 protein, human
Calcium
Left Ventricular Structure
Resting Potentials
Potassium
Action Potentials
Anti-Arrhythmia Agents

Feeds With Similar Papers

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Paper Details
References
  • References16
  • Citations14
12
  • References16
  • Citations14
12

Download from

Publisher
PubMed
/papers/investigations-to-characterize-a-new-anti-arrhythm/7336