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Investigations to characterize a new anti-arrhythmic drug, ORG 6001 including a simple test for calcium antagonism

British Journal of Pharmacology

Jun 1, 1976

Lateef A SalakoJ H Wittig

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Abstract

1 The compound Org 6001 (3alpha-amino-2beta-hydroxy-5alpha-androstan-17-one hydrochloride) was found in recent experiments to exhibit anti-arrhythmic activity. Evidence is presented in this paper concerning its mode of action. 2 Org 6001 was 1.8 times more potent than procaine as a loca...read more

Mentioned in this Paper

Org 6001
Potassium
Local Anesthetics
Procaine
Myocardial Contraction
Xeroderma Pigmentosum, Variant Type
Detection of Muscle Activity
Structure of Sciatic Nerve
Calcium [EPC]
Metazoa
Paper Details
References
  • References16
  • Citations14
12
  • References16
  • Citations14
12

Investigations to characterize a new anti-arrhythmic drug, ORG 6001 including a simple test for calcium antagonism

British Journal of Pharmacology

Jun 1, 1976

Lateef A SalakoJ H Wittig

PMID: 7336

DOI: 10.1111/j.1476-5381.1976.tb07475.x

Abstract

1 The compound Org 6001 (3alpha-amino-2beta-hydroxy-5alpha-androstan-17-one hydrochloride) was found in recent experiments to exhibit anti-arrhythmic activity. Evidence is presented in this paper concerning its mode of action. 2 Org 6001 was 1.8 times more potent than procaine as a loca...read more

Mentioned in this Paper

Org 6001
Potassium
Local Anesthetics
Procaine
Myocardial Contraction

Related Papers

Paper Details
References
  • References16
  • Citations14
12
  • References16
  • Citations14
12

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