Investigative MRI cholangiopancreatography for primary sclerosing cholangitis-type lesions in children with IBD

Journal of Pediatric Gastroenterology and Nutrition
Efthymia AlexopoulouNikolaos L Kelekis

Abstract

The aim of the study was to estimate the frequency of primary sclerosing cholangitis (PSC)-type lesions in children with inflammatory bowel disease (IBD) by means of magnetic resonance cholangiopancreatography (MRCP), and to investigate the association between a series of easily applicable data on the one hand and the presentation of such lesions at MRCP on the other hand. Collected demographic, laboratory, and magnetic resonance enterography data from the records of 73 children with IBD were cross-sectionally related to the MRCP-based diagnosis. Around the time of MRCP, the distribution of IBD subtypes was 64.4%, 24.7%, and 11% for Crohn disease, indeterminate colitis, and ulcerative colitis, respectively. A total of 11 patients (15.1%) were identified with PSC-type lesions. Demographic and magnetic resonance enterography data were unrelated to the MRCP outcome. Biochemical abnormalities were of low prevalence (<50%) among patients with PSC. The abnormality prevalences of aspartate transaminase, alanine transaminase, and γ-glutamyl transferase were significantly higher in the PSC group, both at initial diagnosis of IBD and at the time of MRCP. Less-consistent results were documented for bilirubin and alkaline phosphatase, espe...Continue Reading

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Dec 30, 2014·Insights Into Imaging·Athanasios AthanasakosEfthymia Alexopoulou
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Aug 22, 2014·Journal of Pediatric Gastroenterology and Nutrition·Hanh D VoSteven M Schwarz
May 10, 2012·Journal of Pediatric Gastroenterology and Nutrition·Guido Engelmann

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