Involution of mouse mammary glands during whole organ culture occurs via apoptosis of epithelial tissue

Cell Biology International
Theresa M CaseyJ F Chiu

Abstract

Apoptosis was measured in mammary glands during whole organ culture, to determine whether regression resulting from hormone withdrawal results in epithelial cell death as in vivo involution. Glands were evaluated for morphology and DNA degradation prior to whole organ culture, after lobulo-alveolar development and 2, 4, or 6 days after hormone withdrawal. The data indicated that mammary regression during whole organ culture mimics in vivo involution and results in part from apoptosis of epithelial tissue.

Citations

Jun 4, 2005·Biotechnology Progress·Benjamin S YounJohn A Hassell
May 12, 2000·Proceedings of the Society for Experimental Biology and Medicine·T M CaseyK Plaut
Apr 20, 2006·Molecular and Cellular Endocrinology·Craig R BaumruckerRobert R Friis
Dec 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E Gallo-HendrikxZ X Xiao

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis