Involved-field radiation therapy for recurrent ovarian cancer: Results of a multi-institutional prospective phase II trial

Gynecologic Oncology
Jee Suk ChangYong Bae Kim

Abstract

To evaluate the efficacy and safety of involved-field radiation therapy (IFRT) in patients with locoregionally confined recurrent or persistent epithelial ovarian cancer. This study included patients with recurrent epithelial ovarian cancer eligible for IFRT either during diagnosis of the recurrence or after salvage therapies. IFRT was performed at a dose of ≥45 Gy for all tumors with 10-15-mm margins as seen on standard imaging. The primary endpoint was progression-free survival (PFS); the secondary endpoints were safety, response rate, local control, and overall survival (OS). Thirty patients with a mean number of 5.7 metastatic lesions each were enrolled between 2014 and 2016. Seventeen were treated with 3-D conformal radiation therapy (RT) and 13 with intensity-modulated RT. IFRT was well tolerated in all patients, and acute toxicity ≥ grade 2 was not observed. One case of grade 3 abdominal pain was reported 10 months post-RT. The overall and complete response rates were 85.7% and 50%, respectively. After a median follow-up of 28 (range, 17-42) months, the median PFS was 7 months. The 2-year PFS rate was 39.3%. Six of the 16 patients who developed outfield disease progression after IFRT were successfully treated with repeat...Continue Reading

Citations

Dec 12, 2018·Current Opinion in Obstetrics & Gynecology·Puja S VenkatPhillip Beron
Apr 16, 2020·Diagnostics·Geraldine Jacobson, Valerie Galvan-Turner
Jun 14, 2020·Current Treatment Options in Oncology·Tina W ZhangLucas C Mendez
Sep 20, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yasushi IidaC Simon Herrington
Jul 25, 2019·The Journal of Obstetrics and Gynaecology Research·Tamina KinoHiroyuki Shigeta
Jul 23, 2019·Journal of Gynecologic Oncology·Nalee KimYong Bae Kim
Jun 26, 2021·Gynecologic Oncology Reports·E A JohnsL M Kuroki
Sep 3, 2021·International Journal of Radiation Oncology, Biology, Physics·Lauren E HenkeAnupama Chundury

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