Involvement of α- and β-catenins and E-cadherin in the development of mammary phyllodes tumours

Histopathology
Julia Y S TsangGary M Tse

Abstract

Phyllodes tumours (PT) are rare but clinically important fibroepithelial tumours of the breast. β-Catenin, a key component in Wnt signalling, has been shown to be important in the development of PT. It also functions as a component of the cadherin complex, which may therefore be implicated in PT pathogenesis. By assessing stromal α-catenin, β-catenin and E-cadherin expression in 158 PT cases using immunohistochemistry and examining associations with clinicopathological features, we aimed to determine the role of these proteins in PT pathogenesis. Cytoplasmic β-catenin correlated with α-catenin expression. A significantly higher expression of both markers was observed in borderline than in benign PT (P = 0.003 and <0.001, respectively), but a lower level was found in malignant PT. Cytoplasmic E-cadherin expression was significantly higher in borderline and malignant than in benign PT (P = 0.001 and 0.012, respectively), but was not correlated with other markers. Both E-cadherin and α-catenin showed stronger correlations with histological parameters than β-catenin. α-Catenin showed a significant correlation with recurrence (P = 0.005 and 0.016, respectively). α- and β-catenins may be important in the early stages of PT developmen...Continue Reading

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Citations

Feb 14, 2013·Journal of Clinical Pathology·Rooshdiya Z KarimCheok Soon Lee
Jan 16, 2016·Histopathology·Benjamin Y TanPuay Hoon Tan
Jan 8, 2013·Virchows Archiv : an International Journal of Pathology·Huang-Chun LienYu-Tung Yao
Jan 15, 2015·Histopathology·Julia Y S TsangGary M Tse
Jul 18, 2020·Cancer Biomarkers : Section a of Disease Markers·Sun Il Kim, Ja Seung Koo
May 30, 2019·Acta Cytologica·Francisco Beca, Fernando C Schmitt

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