Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice

Acta Dermato-venereologica
Nobuaki TakahashiKenji Takamori

Abstract

The pathogenesis of psoriatic itch is poorly understood. The aim of this study was to investigate the involvement of opioid receptors in scratching behaviour of imiquimod-induced psoriasis-like dermatitis model mice. Topical application of 5% imiquimod cream to the rostral back skin of mice induced antihistamine-resistant scratching behaviour. The expression of µ-opioid receptor (MOR) protein increased in the epidermis, dorsal root ganglia (DRG) and spinal cord of imiquimod-treated mice. In contrast, the expression of κ-opioid receptor (KOR) protein decreased in the DRG and spinal cord of imiquimod-treated mice, and was undetectable in the epidermis of both groups. Topical or intraperitoneal administration of the MOR antagonist naloxone and oral administration of the centrally acting KOR agonist ICI-199,441 inhibited scratching behaviour, whereas oral administration of the peri-pherally-selective KOR agonist asimadoline did not. These results suggest that peripheral and central MOR and central KOR may be involved in the modulation of scratching behaviour in imiquimod-treated mice.

Citations

Sep 7, 2018·Clinical and Experimental Dermatology·T NakamuraT Mochizuki
Jan 22, 2019·The Journal of Dermatological Treatment·Deeti J PithadiaJashin J Wu
Jan 19, 2020·Experimental Dermatology·Marissa T AyasseMartin Steinhoff
Mar 15, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·A WieczorekJ C Szepietowski
Jun 26, 2020·Neuropsychopharmacology Reports·Norikazu KiguchiShiroh Kishioka
Dec 6, 2019·Peptides·Richard J Bodnar
Jan 21, 2021·International Journal of Molecular Sciences·Kamila JaworeckaAdam Reich
Nov 14, 2020·International Journal of Molecular Sciences·Eriko KomiyaKenji Takamori
Aug 20, 2021·The Journal of Allergy and Clinical Immunology·Eriko KomiyaKenji Takamori
Nov 29, 2021·Experimental Dermatology·Rosanna MarsellaChristoph Abels

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