Involvement of α2-adrenoceptor subtypes A and C in glucose homeostasis and adrenaline-induced hyperglycaemia

Neuroendocrinology
Suvi T RuohonenLutz Hein

Abstract

Insulin secretion is controlled by pancreatic α(2A)-adrenoceptors. Mice lacking α(2A)-adrenoceptors (α(2A)AR(-/-) mice) show hyperinsulinaemia, reduced blood glucose levels and improved glucose tolerance. In the present study, we used α(2AC)AR(-/-), α(2C)AR(-/-) and α(2A)AR(-/-) mice and a mouse line with adrenergic cell-specific expression of α(2A)-adrenoceptors (lacking these receptors in non-adrenergic cells), and their wild-type (WT) controls, to assess the glucoregulatory role of the α(2C)-adrenoceptor subtype in vivo. Glucose and insulin tolerance tests were performed and blood glucose and serum insulin levels were determined after fasting and glucose stimulation. Plasma catecholamines were also measured. In addition, the effect of pretreatment with (±)-propranolol was determined in α(2C)AR(-/-) mice. α(2AC)AR(-/-) mice had a similar glucose and insulin phenotype as α(2A)AR(-/-) mice and mice with restored α(2A)-autoreceptors, suggesting that only deletion of postsynaptic α(2A)-adrenoceptors has major effects on glucose disposition. However, α(2AC)AR(-/-) mice were more sensitive to the glucose-lowering effect of insulin than WT mice. This was not observed in α(2A)AR(-/-) mice. The α(2C)AR(-/-) mice showed impaired glucos...Continue Reading

References

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Citations

Sep 3, 2014·Respiratory Physiology & Neurobiology·Mi-Kyung ShinVsevolod Y Polotsky
Jul 2, 2015·Basic & Clinical Pharmacology & Toxicology·Suvi T RuohonenTomi Streng
Nov 13, 2012·Journal of Neuroendocrinology·H N BoydaA M Barr
Oct 21, 2019·Clinical and Experimental Pharmacology & Physiology·Patricia C BorckSabrina Grassiolli
Sep 29, 2015·Sleep and Biological Rhythms·Omar A MesarwiVsevolod Y Polotsky
Jun 15, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Bayan MesmarRana Malek

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