Involvement of 5-HT(2C) receptors in the anti-immobility effects of antidepressants in the forced swimming test in mice

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
F ClenetM Bourin

Abstract

Several recent studies have demonstrated that 5-HT(1A), 5-HT(1B) and 5-HT(3) receptors were implicated in the mechanism of action of antidepressants in the mouse forced swimming test. Despite extensive evidence for a role of 5-HT(2C) receptors in depression, the precise role of these receptors in the effects of clinically established antidepressants was not directly investigated in the mouse forced swimming test. This work was aimed at exploring interactions between several doses of Ro 60-0175, a recently available, full and selective 5-HT(2C) agonist, and antidepressant drugs in the mouse forced swimming test. Spontaneous locomotor activity was measured as an index of intact sensorimotor functions and the dose-effect of Ro 60-0175 alone, as well as interactions with several antidepressants, such as tricyclic antidepressants (imipramine, desipramine and maprotiline) and selective serotonin reuptake inhibitors (paroxetine, citalopram, fluoxetine, fluvoxamine and sertraline), were studied in the mouse forced swimming test. There was no intrinsic antidepressant-like effect of Ro 60-0175, but an impairment in locomotor function was detected when using doses higher than 4 mg/kg in the mouse. There was a synergistic effect of low dos...Continue Reading

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Citations

Dec 21, 2004·Psychopharmacology·Benoit Petit-DemouliereMichel Bourin
Feb 14, 2007·Psychopharmacology·Sharon Rosenzweig-LipsonKaren L Marquis
Nov 26, 2010·Psychopharmacology·Gregory V Carr, Irwin Lucki
Mar 19, 2013·Behavioural Brain Research·Amber LockridgeLi-Lian Yuan
Oct 25, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kiyomi Matsuzawa-YanagidaTsutomu Suzuki
Aug 25, 2012·Expert Opinion on Investigational Drugs·Gaël QuesseveurBruno P Guiard
Dec 23, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andiara E FreitasAna Lúcia S Rodrigues
Sep 18, 2004·Brain Research·Andréa Dias Elpo ZomkowskiAna Lúcia Severo Rodrigues
Mar 5, 2004·Expert Opinion on Therapeutic Targets·Alessandro SerrettiDiana De Ronchi
Feb 16, 2010·Neuropharmacology·Magdalena ZaniewskaMałgorzata Filip
Feb 23, 2010·Pharmacology, Biochemistry, and Behavior·Güner UlakB Faruk Erden
Aug 10, 2005·Behavioural Brain Research·Michel BourinDenis Joseph Paul David
Aug 28, 2021·International Journal of Molecular Sciences·Grzegorz ŚlifirskiJadwiga Turło

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