Involvement of α7nAChR in the Protective Effects of Genistein Against β-Amyloid-Induced Oxidative Stress in Neurons via a PI3K/Akt/Nrf2 Pathway-Related Mechanism.

Cellular and Molecular Neurobiology
Jianbin GuoHao Yang

Abstract

Abnormal excessive production and deposition of β-amyloid (Aβ) peptides in selectively susceptible brain regions are thought to be a key pathogenic mechanism underlying Alzheimer's disease (AD), resulting in memory deficits and cognitive impairment. Genistein is a phytoestrogen with great promise for counteracting diverse Aβ-induced insults, including oxidative stress and mitochondrial dysfunction. However, the exact molecular mechanism or mechanisms underlying the neuroprotective effects of genistein against Aβ-induced insults are largely uncharacterized. To further elucidate the possible mechanism(s) underlying these protective effects, we investigated the neuroprotective effects of genistein against Aβ-induced oxidative stress mediated by orchestrating α7 nicotinic acetylcholine receptor (α7nAChR) signaling in rat primary hippocampal neurons. Genistein significantly increased cell viability, reduced the number of apoptotic cells, decreased accumulation of reactive oxygen species (ROS), decreased contents of malondialdehyde (MDA) and lactate dehydrogenase (LDH), upregulated BCL-2 expression, and suppressed Caspase-3 activity occurring after treatment with 25 μM Aβ25-35. Simultaneously, genistein markedly inhibited the decreas...Continue Reading

References

Nov 5, 2002·Nature Reviews. Neuroscience·Frank M LaFerla
Mar 24, 2005·Journal of Cellular and Molecular Medicine·Gang SongShideng Bao
Aug 30, 2005·Journal of Structural Biology·Ritu KhuranaShashi Singh
Oct 5, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bruno BitonBernard Scatton
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Marina R Picciotto, Michele Zoli
Jul 16, 2008·Journal of Cellular and Molecular Medicine·Dietmar Rudolf ThalHeiko Braak
Aug 8, 2008·Neurochemical Research·Rudimar Luiz FrozzaChristianne Gazzana Salbego
Mar 9, 2010·Current Alzheimer Research·L GuoM F Cordeiro
Sep 23, 2010·Journal of Alzheimer's Disease : JAD·Gerard Ill-RagaFrancisco J Muñoz
Oct 23, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kyeong-Ah Jung, Mi-Kyoung Kwak
Jun 6, 2012·Neurology·V W HendersonUNKNOWN WISH Research Group
Mar 26, 2014·Neuroscience Bulletin·Zhichun Chen, Chunjiu Zhong
Dec 4, 2014·Trends in Pharmacological Sciences·Sharadha Dayalan NaiduAlbena T Dinkova-Kostova
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Carey E GleasonSanjay Asthana
Nov 18, 2015·Oxidative Medicine and Cellular Longevity·Seyedeh Maryam Alavi Naini, Nadia Soussi-Yanicostas
May 18, 2016·Trends in Pharmacological Sciences·Jie WuJerrel L Yakel
Sep 14, 2017·Current Neuropharmacology·Michele ZoliCecilia Gotti

❮ Previous
Next ❯

Citations

Jan 13, 2021·International Journal of Molecular Sciences·Yoshihiko Kakinuma
Mar 12, 2021·Brain and Behavior·Xiaoying DuanHong Ding
Jun 25, 2021·Frontiers in Neurology·Ibrahim MortadaNajwane Said Sadier
Jul 23, 2021·Cancer Cell International·Zeeshan JavedJavad Sharifi-Rad
Nov 7, 2021·Cellular and Molecular Life Sciences : CMLS·Rohan Gupta Pravir Kumar

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA
PCR
pharmacotherapy
nuclear translocation

Software Mentioned

SPSS
Zeiss LSM Imaging

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.