PMID: 6400436Oct 1, 1983Paper

Involvement of a cathepsin B-like cysteine proteinase in platelet aggregation induced by tumor cells and their shed membrane vesicles

Clinical & Experimental Metastasis
P G CavanaughK V Honn

Abstract

Murine 15091A mammary adenocarcinoma cells and membrane vesicles spontaneously shed from these tumor cells in culture can induce aggregation of washed human platelets. A spectrum of proteinase inhibitors was tested for their ability to inhibit 15091A induced platelet aggregation. Of the inhibitors tested the most effective were those selective for cysteine proteinases. The effect of the spectrum of proteinase inhibitors on 15091A induced platelet aggregation was compared to the effect on cathepsin B-like cysteine proteinase activity in homogenates of 15091A tumor cells and their spontaneously shed vesicles. The results suggest that there is a correlation between activity of a cathepsin B-like proteinase in 15091A cells and vesicles and the ability of these cells and vesicles to induce aggregation of washed human platelets.

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Citations

Jan 1, 1984·Cancer Metastasis Reviews·G J Gasic
Jan 1, 1984·Cancer Metastasis Reviews·B F Sloane, K V Honn
Dec 1, 1990·Cancer Metastasis Reviews·B F SloaneJ Rozhin
Jan 1, 1986·Cancer Metastasis Reviews·R G Greig, D L Trainer
Nov 1, 1992·Cancer Metastasis Reviews·S G Gordon, M Chelladurai
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B F SloaneK V Honn
Jan 13, 2006·Annual Review of Pharmacology and Toxicology·Bonnie F SloaneKamiar Moin
Apr 4, 2014·Cancer Metastasis Reviews·David G MenterKenneth V Honn
Mar 29, 2014·Proteomics. Clinical Applications·Neha Aggarwal, Bonnie F Sloane
Dec 1, 1985·Cancer Treatment Reviews·R B LichtnerK Hellmann
Jan 29, 2014·BMC Cancer·Stefan KrugerReza Izadpanah
Aug 1, 1990·Japanese Journal of Cancer Research : Gann·S M Chung
Jun 5, 2013·Experimental Cell Research·Kirsi RillaMarkku I Tammi
Jul 16, 2011·Cancer Treatment Reviews·J GongM Bebawy
Aug 27, 2014·Journal of Internal Medicine·L Badimon, G Vilahur
Oct 15, 1988·International Journal of Cancer. Journal International Du Cancer·G GrignaniM B Donati
Oct 1, 1987·Biochemical Medicine and Metabolic Biology·D Petrova-SkalkováJ Vicar

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