PMID: 2508752Oct 9, 1989Paper

Involvement of a specific guanine nucleotide binding protein in receptor immunoglobulin stimulated inositol phospholipid hydrolysis

Biochimica Et Biophysica Acta
J G Monroe, S Haldar

Abstract

The role of a specific guanine nucleotide binding (G protein) protein in coupling murine B lymphocyte receptor immunoglobulin to inositol phospholipid hydrolysis was investigated. Using an in vitro system with isolated membranes, we have observed specific enhancement of GTP binding subsequent to ligand-induced receptor crosslinking. Induced increases were inhibited by pretreatment with pertussis toxin which catalyzed ADP-ribosylation of a 43 kDa substrate. Involvement of this G protein with receptor immunoglobulin-induced inositol phospholipid hydrolysis was evidenced by the ability of pertussis toxin to block this response. This report, then, indicates that the B lymphocyte antigen receptor belongs to a family of receptors which are linked to inositol phospholipid hydrolysis through a G protein.

References

Jul 1, 1985·Cell·M K BijsterboschG G Klaus
Jan 1, 1987·Annual Review of Immunology·J C Cambier, J T Ransom
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R K ReynoldsG Jay
Jan 1, 1986·Annual Review of Cell Biology·L Stryer, H R Bourne
Jan 1, 1987·Annual Review of Biochemistry·A G Gilman
Jan 1, 1988·Immunologic Research·J G Monroe, V L Seyfert
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J J MondG Dennis
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J E McCormackG E Sonenshein
Jan 1, 1982·Annals of the New York Academy of Sciences·P W TuckerF R Blattner

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Citations

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R H CarterD T Fearon
Jul 1, 1992·The Journal of Experimental Medicine·A J Yellen-Shaw, J G Monroe
Apr 1, 1993·Immunological Reviews·T YamamotoK Toyoshima

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