Involvement of aberrant glycosylation in thyroid cancer.

Journal of Oncology
Eiji MiyoshiYoko Miyoshi

Abstract

Glycosylation is one of the most common posttranslational modification reactions and nearly half of all known proteins in eukaryotes are glycosylated. In fact, changes in oligosaccharides structures are associated with many physiological and pathological events, including cell growth, migration and differentiation, and tumor invasion. Therefore, functional glycomics, which is a comprehensive study of the structures and functions of glycans, is attracting the increasing attention of scientists in various fields of life science. In cases of thyroid cancer, the biological characters and prognosis are completely different in each type of histopathology, and their oligosaccharide structures as well as the expression of glycosyltransferases are also different. In this review, we summarized our previous papers on oligosaccharides and thyroid cancers and discussed a possible function of oligosaccharides in the carcinogenesis in thyroid cancer.

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Citations

Apr 11, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Bhairavi N VajariaPrabhudas S Patel
Oct 30, 2016·Journal of Surgical Oncology·Shih-Ping ChengChien-Liang Liu
Jan 18, 2018·Prostate Cancer and Prostatic Diseases·Naseruddin HötiHui Zhang
Apr 3, 2020·International Journal of Oncology·Byoungjae KimSeung-Kuk Baek
Sep 20, 2018·International Journal of Molecular Sciences·Marta ZąbczyńskaEwa Pocheć
Aug 6, 2019·Clinical and Experimental Pharmacology & Physiology·Siyao WangShun Xu
Jan 21, 2021·International Journal of Molecular Sciences·Kayla BastianJennifer Munkley

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Methods Mentioned

BETA
protein folding
glycosylation
enzyme-linked immunosorbent assay
transfection
ELISA

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