PMID: 9430562Jan 16, 1998Paper

Involvement of aldose reductase in naphthalene cataract

Investigative Ophthalmology & Visual Science
A Y Lee, S S Chung

Abstract

The authors investigated the involvement of the enzyme aldose reductase (AR) in naphthalene cataract by using transgenic mice that overexpress AR. Lenses from nontransgenic mice and from transgenic lines CAR222 and CAR648, with different levels of AR, were cultured in medium containing naphthalene-1,2-dihydrodiol (ND) with or without AR inhibitor AL1576. The morphology and progression rate of ND-induced cataract in these lenses were compared. Lenses from transgenic mice CAR222 and CAR648, but not their nontransgenic littermates, developed yellow pigment in the inner cortex when exposed to 50 microM ND, which was completely prevented by 0.2 mM AL1576. The yellow pigment developed faster and more intensely in the CAR648 lens, which has a higher AR level than CAR222. Under a high dose of 500 microM ND, both transgenic and wild-type mouse lenses developed ND-induced cataract, although the first sign of cataract was found in the outer cortex in transgenic lenses instead of the inner cortical region in wild-type lenses. In addition, the cataract was more severe and developed at a faster rate in transgenic mouse lenses. AL1576 showed only partial protection against the cataract induced by 500 microM ND. The findings showed that the pr...Continue Reading

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