PMID: 9658094Jul 11, 1998Paper

Involvement of aminopeptidase N (CD13) in infection of human neural cells by human coronavirus 229E

Journal of Virology
C LachancePierre J Talbot

Abstract

Attachment to a cell surface receptor can be a major determinant of virus tropism. Previous studies have shown that human respiratory coronavirus HCV-229E uses human aminopeptidase N (hAPN [CD13]) as its cellular receptor for infection of lung fibroblasts. Although human coronaviruses are recognized respiratory pathogens, occasional reports have suggested their possible neurotropism. We have previously shown that human neural cells, including glial cells in primary cultures, are susceptible to human coronavirus infection in vitro (A. Bonavia, N. Arbour, V. W. Yong, and P. J. Talbot, J. Virol. 71:800-806, 1997). However, the only reported expression of hAPN in the nervous system is at the level of nerve synapses. Therefore, we asked whether hAPN is utilized as a cellular receptor for infection of these human neural cell lines. Using flow cytometry, we were able to show the expression of hAPN on the surfaces of various human neuronal and glial cell lines that are susceptible to HCV-229E infection. An hAPN-specific monoclonal antibody (WM15), but not control antibody, inhibited the attachment of radiolabeled HCV-229E to astrocytic, neuronal, and oligodendrocytic cell lines. A correlation between the apparent amount of cell surface...Continue Reading

References

May 1, 1976·Journal of the Neurological Sciences·R TanakaH Koprowski
May 1, 1992·Annals of Neurology·R S MurrayG F Cabirac
May 1, 1990·The Journal of General Virology·T RaabeS G Siddell
Apr 1, 1989·The Journal of Clinical Investigation·A T LookS C Peiper
Apr 15, 1995·Cellular Immunology·T H Piela-Smith, J H Korn
May 1, 1994·Microbial Pathogenesis·G F CabiracR S Murray
Nov 1, 1993·Journal of Virology·C SöderbergE Möller
Jan 1, 1993·Advances in Experimental Medicine and Biology·P J TalbotJ N Stewart
Jan 1, 1995·Advances in Experimental Medicine and Biology·B DelmasH Laude
Jan 1, 1995·Advances in Experimental Medicine and Biology·G F CabiracP J Didier
Oct 1, 1996·The Journal of General Virology·A F KolbS G Siddell
Apr 1, 1997·Journal of Virology·M J Bouchard, V R Racaniello
Feb 1, 1997·Journal of Neurovirology·R S MurrayG F Cabirac
Oct 23, 1998·Advances in Experimental Medicine and Biology·N Arbour, P J Talbot

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Citations

May 17, 2000·The Journal of General Virology·J Schneider-Schaulies
Jun 21, 2015·Journal of Neurovirology·Frances ZenónLoyda M Melendez
Nov 17, 2007·Heart Failure Reviews·Robert S Danziger
Jul 21, 2020·AIDS Research and Human Retroviruses·Lena Al-HarthiDavid A Bennett
Nov 30, 2005·Transgenic Research·Caroline LassnigMathias Müller
Jul 10, 2020·Journal of Virology·Xuesen ZhaoJu-Tao Guo
May 18, 2020·Journal of Neurovirology·Ali SepehrinezhadSajad Sahab Negah
Feb 23, 2019·Viruses·Antonio C P WongPatrick C Y Woo
Sep 26, 2020·Frontiers in Neurology·Gilmara Gomes de AssisEugene V Gasanov
Sep 29, 2020·Frontiers in Immunology·Inmaculada Sanclemente-AlamanUlises Gómez-Pinedo
May 6, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Danila CianciosiFrancesca Giampieri
Jun 20, 2021·Nature Communications·Teresa AydilloAdolfo García-Sastre

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