Involvement of angiotensin receptor subtypes in osmotically induced release of vasopressin

Brain Research
D C HogartyM I Phillips

Abstract

We have previously shown that AT1 and AT2 angiotensin II (Ang II) receptors mediate the release of arginine vasopressin (AVP) to central injections of Ang II. In this study we have tested the hypothesis that Ang II, acting at AT1 and AT2 receptors in the brain, is involved in mediating osmotically stimulated AVP release. Adult Sprague-Dawley rats were fitted with intraventricular (i.v.t.) cannulas and catheters in the carotid artery and the femoral vein. Intraventricular injections of Ang II receptor antagonists specific to different subtypes of the receptor (AT1 and AT2) were given before a 30 min infusion of hypertonic (2.5 M) saline. Arterial blood samples were collected 5 min before and at two time points after (+15 min and +30 min) beginning the saline infusion. We found that both losartan (AT1 specific) and CGP42112A (AT2 specific) significantly reduced osmotically induced release of AVP. PD123319 (AT2 specific) had no effect of osmotically stimulated AVP release. A combined treatment of losartan + PD123319 was no more effective than losartan in blocking the AVP response. Since losartan was the most rapid and effective antagonist of osmotically stimulated AVP release, we conclude that AT1 receptors are directly involved i...Continue Reading

References

Jul 1, 1976·Kidney International·G L RobertsonS Athar
Apr 1, 1975·Endocrinology·L C KeilW B Severs
Sep 1, 1977·Neuropharmacology·W E HoffmanP Schmid
Oct 6, 1971·Nature: New Biology·R A Nicoll, J L Barker
Mar 1, 1982·Clinical and Experimental Pharmacology & Physiology·J F MannJ Genest
Mar 19, 1993·Regulatory Peptides·M I PhillipsM K Raizada
Dec 16, 1947·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E B VERNEY

Citations

Nov 10, 1995·Regulatory Peptides·J W Wright, J W Harding
Oct 9, 2002·Neuroscience and Biobehavioral Reviews·John W WrightJ W Harding
Nov 25, 1997·Brain Research. Brain Research Reviews·J W Wright, J W Harding
Mar 1, 2003·Regulatory Peptides·Steven L Bealer, William R Crowley
Jan 8, 1999·Regulatory Peptides·M I Phillips, C Sumners
Feb 5, 1999·Brain Research. Molecular Brain Research·S W Barth, R Gerstberger
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·M J McKinleyS Y Chai
Sep 1, 1996·Clinical and Experimental Pharmacology & Physiology·M J McKinleyBrian J Oldfield
Nov 1, 1995·Pharmacology & Toxicology·S HöhleT Unger
Aug 9, 2001·The Japanese Journal of Physiology·M J McKinleyR S Weisinger
Jun 25, 2008·Stress : the International Journal on the Biology of Stress·Agnieszka Cudnoch-JedrzejewskaAgnieszka Wsół
Jul 29, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Gabriela Maria Pavan de Arruda CamargoWilson Abrão Saad
Feb 22, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael J McKinleyDerek A Denton
Jan 13, 2004·Physiological Reviews·José Antunes-RodriguesSamuel M McCann
Feb 17, 2000·The Annals of Pharmacotherapy·Z H ShaikhL A Llerena
Jul 31, 1998·The American Journal of Physiology·T J McDonaldM G Ross
Nov 27, 2015·American Journal of Physiology. Renal Physiology·Alexis A GonzalezMinolfa C Prieto
Mar 1, 1996·The American Journal of Physiology·J A SaydoffM S Brownfield
Sep 23, 1996·The Journal of Comparative Neurology·Z LenkeiC Llorens-Cortes

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