Involvement of apoptosis and calcium accumulation through TRPV1 channels in neurobiology of epilepsy

Neuroscience
Mustafa Nazıroğlu, I S Ovey

Abstract

Calcium ion accumulation into the cytosol of the hippocampus and dorsal root ganglion (DRG) are main reasons in etiology of epilepsy. Transient receptor potential vanilloid type 1 (TRPV1) channel is a cation-permeable calcium channel found in the DRG and hippocampus. Although previous studies implicate TRPV1 channels in the generation of epilepsy, suppression of ongoing seizures by TRPV1 antagonists has not yet been investigated. We tested the effects of TRPV1-specific antagonists, capsazepine (CPZ) and 5'-iodoresiniferatoxin (IRTX) on the modulation of calcium accumulation, apoptosis and anticonvulsant properties in the hippocampus and DRG of pentylentetrazol (PTZ) and capsaicin (CAP) administrated rats. Forty rats were divided into five groups as follows; control, PTZ, CAP+PTZ, IRTX, and IRTX+PTZ. Fura-2 and patch-clamp experiments were performed on neurons dissected from treated animals by CAP and CPZ. PTZ and CAP+PTZ administrations increased intracellular free Ca(2+) concentrations, TRPV1 current densities, apoptosis, caspase 3 and 9 values although the values were reduced by IRTX and CPZ treatments. Latency time was extended by application CPZ and IRTX although CAP produced acceleration of epileptic seizures. Taken togeth...Continue Reading

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Citations

Apr 8, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fa-Xiang WangQing-Wu Yang
Mar 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min Hee YangKwang Seok Ahn
Jul 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hasan TurkezDamião Pergentino de Sousa
Jun 18, 2020·International Journal of Molecular Sciences·Kevin ZhaiDietrich Büsselberg
Feb 9, 2021·Frontiers in Behavioral Neuroscience·Giselda Cabral-PereiraRicardo Gómez-Nieto
Mar 23, 2021·Frontiers in Cell and Developmental Biology·Kihwan LeeChul-Kyu Park
Dec 17, 2019·Epilepsy & Behavior : E&B·Laila AsthFabrício A Moreira

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis