Involvement of arginine vasopressin in endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
J Jochem

Abstract

Histamine is a potent stimulator of arginine vasopressin (AVP) release and therefore, the role of AVP was studied in the reversal of critical haemorrhagic hypotension induced by endogenous central histamine after inhibition of histamine N-methyltransferase (HNMT) activity in rats. In 48 ethylurethane-anaesthetised male Wistar rats cardiovascular parameters and plasma hormone concentrations were measured. Haemorrhage-shocked rats with mean arterial pressure (MAP) 20-25 mmHg were injected intracerebroventricularly (icv) with HNMT inhibitor metoprine (20 microg) after pre-treatment with V(1a), V(1b) and V(2) receptor antagonists - [beta-mercapto-beta,betacyclopentamethylenepropionyl(1), O-me-Tyr(2),Arg(8)]AVP (10 microg/kg; iv), SSR149415 (10 mg/kg; ip) and [adamantaneacetyl(1),O-Et-D-Tyr(2),Val(4), aminobutyryl(6),Arg(8,9)]AVP (10 microg/kg; iv), respectively, or saline. MAP, heart rate (HR) and regional haemodynamics were monitored within 2 h after treatment or to death if it occurred earlier. Plasma hormone concentrations were measured using enzyme immunoassays. ANOVA followed by Neuman-Keules test, and Fisher's exact test were used to compare the results. Metoprine produced a long-lasting increase in MAP, HR, renal, hindquarte...Continue Reading

Citations

Dec 4, 2014·Autonomic Neuroscience : Basic & Clinical·Burcin AltinbasMurat Yalcin
Sep 15, 2005·Physiological Genomics·P D BowmanG M Vaughan
Apr 22, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R Frithiof, M Rundgren
Jan 11, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Itsuro MatsumotoTadaomi Aikawa

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