PMID: 8604810Apr 1, 1996Paper

Involvement of BCL-2 oncoprotein in the development of enterochromaffin-like cell gastric carcinoids

The American Journal of Surgical Pathology
C AzzoniC Bordi

Abstract

To evaluate the involvement of the apoptosis-suppressing protein BCL-2 in the gastrin-dependent mechanism of induction of gastric enterochromaffin-like (ECL) cell carcinoids, the endocrine cell of the oxyntic mucosa were immunohistochemically investigated in (a) 10 normogastrinemic subjects with histologically normal gastric mucosa; (b) 22 patients with endocrine cell hyperplasia and affected by hypergastrinemic conditions with different risk of gastric carcinoid development, such as sporadic Zollinger-Ellison syndrome (sZES; n = 9), ZES associated with multiple endocrine neoplasia-1 (MEN-1; n = 4), and atrophic fundal gastritis (AFG; n = 9); (c) 14 patients with ECL gastric carcinoids accounting for a total of 31 tumors investigated. In the normal oxyntic mucosa, BCL-2 was consistently expressed by a subset of endocrine cells accounting for 50.0% (median; range, 24.6-74.0%) of the total number of endocrine cells immunostained for chromogranin A (CgA) in consecutive sections. BCL-2 immunoreactive cells were located mostly in the middle mucosal layer, suggesting a role for the protein during downward migration of maturing endocrine cells. No BCL-2 immunoreactivity was found in other specialized gastric epithelial cells. Expressi...Continue Reading

References

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D M HockenberyS J Korsmeyer
Jan 1, 1990·Digestion·Y TielemansR Håkanson
Aug 1, 1989·Annals of Medicine·K Borch
Jan 1, 1988·Digestion·W Creutzfeldt
Jul 1, 1994·The British Journal of Dermatology·B R SmollerR A Warnke
Jan 28, 1993·Nature·M D JacobsonM C Raff
Sep 2, 1993·The New England Journal of Medicine·F PezzellaD Y Mason

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Citations

Dec 31, 2003·Journal of the American College of Surgeons·Irvin M ModlinMark Kidd
May 14, 1999·General Pharmacology·D ChenR Håkanson
Aug 30, 2003·Surgical Oncology·Irvin M ModlinMark Kidd
Oct 31, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·V D CorletoR T Jensen
Oct 22, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·V D CorletoB Annibale
Feb 22, 2001·Annual Review of Physiology·E Rozengurt, J H Walsh
Aug 23, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·D M PritchardA Varro
Mar 27, 2001·AJR. American Journal of Roentgenology·A J BinstockJ G Fletcher
Jan 1, 2009·Folia Histochemica Et Cytobiologica·Tomasz MarkiewiczWojciech Kozlowski
May 14, 2009·World Journal of Gastroenterology : WJG·Sara MassironiDario Conte
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·James C Yao
Oct 25, 2006·Alimentary Pharmacology & Therapeutics·M D Burkitt, D M Pritchard
Dec 8, 2004·Biochemical and Biophysical Research Communications·I S CaddenA McGinty
May 22, 2003·Progress in Histochemistry and Cytochemistry·Luis M MontuengaAna C Villaro
Mar 9, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M KawaharaK Takubo
Oct 29, 2005·Best Practice & Research. Clinical Gastroenterology·Gianfranco Delle FaveFrancesco Panzuto
Jan 9, 2007·European Journal of Gastroenterology & Hepatology·Adriana V Safatle-RibeiroJoaquim Gama-Rodrigues
Nov 1, 2005·Cancer·Michelle N ZikusokaIrvin M Modlin
Mar 4, 2000·Microscopy Research and Technique·C BordiG Ferraro
Dec 24, 2003·Acta Oncologica·Isac I SchnirerJaffer A Ajani
Jan 22, 2005·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·L KölbyH Ahlman

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