Involvement of Bone Marrow Multipotent Stromal Cells in the Processes Presumably Provoking Vascular Calcification.

Bulletin of Experimental Biology and Medicine
Yu F GorskayaV G Nesterenko

Abstract

During serial transplantation of bone marrow derived from young and aged donor CBA mice to 5-month-old recipients, the counts of multipotent stromal cells (MSC) in transplants from young donors assessed at each passage surpassed those of aged donors by 3.2, 7.8, 3.0, and 2.2 times attesting to the age-related decrease of active pool of bone marrow MSC. The medullary curettage in mouse femur increased the total number of MSC and the number of osteogenic MSC both in the contralateral femur and in the bone marrow transplants attesting to spread of the effects of osteogenic factors after bone injury onto the bone tissue of the body even if this tissue if not topographically related to the skeleton. Combined and simultaneous administration of antigenic complex of S. typhimurium (or LPS) with BMP-2 markedly increased the count of osteogenic medullary MSC by 3.6 or 4.6 times in comparison with intact control or by 2.1 and 2.7 times in comparison with administration of BMP-2 alone, which probably resulted from enlargement of the pool of osteogenesis-inducible MSC due to inflammation. Addition of BMP-2 to the culture of splenic stromal cells where osteogenesis does not occur under normal conditions provoked appearance of MSC colonies wi...Continue Reading

References

Jul 8, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elizabeth C WahlCharles K Lumpkin
Jan 10, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Matthias DerwallPaul B Yu
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Nov 29, 2014·American Journal of Hypertension·Mohsen AgharaziiDarren E Richard
Jan 26, 2017·Medicine·Nasser M Al-DaghriFahad Badr M Al-Badr
Sep 3, 2018·Atherosclerosis·Kyoung Im ChoKwang Kon Koh
Oct 10, 2018·Nephrology·Yi-Chou HouKuo-Cheng Lu
Jan 17, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Marissa A RuehleNick J Willett

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