Involvement of bradykinin B2 and muscarinic receptors in the prolonged diuretic and antihypertensive properties of Echinodorus grandiflorus (Cham. & Schltdl.) Micheli

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Thiago Buno Lima PrandoArquimedes Gasparotto Júnior

Abstract

Although Echinodorus grandiflorus (Cham. & Schltr.) Michel are used in Brazilian folk medicine as a diuretic drug, to date, no study has evaluated the mechanisms involved in this activity after prolonged administration in rats. Evaluate the possible mechanisms involved in the prolonged diuretic activity of ethanol soluble fraction obtained from Echinodorus grandiflorus (ES-EG) and to assess its relationship with hypotensive and antihypertensive activity using normotensive rats and those with renovascular hypertension (2K1C). The diuretic effects of ES-EG (30-300 mg/kg; p.o.) were compared with hydrochlorothiazide in a repeated-dose treatment for 7 days. The urinary volume and sodium, potassium, chloride, bicarbonate contents, conductivity, pH and density were estimated in sample collected in 24 h for 7 days. Plasma sodium, potassium, total protein, urea, creatinine, aldosterone, vasopressin, nitrite, acetylcholinesterase concentration and angiotensin converting enzyme (ACE) activity were measured in samples collected at the end of the experimental period (seventh day). Using pharmacological antagonists or inhibitors, the involvement of bradykinin, prostaglandin, acetylcholine and nitric oxide (NO) in ES-EG-induced diuresis was ...Continue Reading

References

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Jul 20, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Eliana de Faria GarciaFernão Castro Braga
Apr 3, 2012·Journal of Ethnopharmacology·Arquimedes Gasparotto JuniorMaria Consuelo Andrade Marques
Jun 25, 2013·Journal of Ethnopharmacology·Priscila de SouzaArquimedes Gasparotto

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Citations

Mar 26, 2016·Frontiers in Pharmacology·M Akhtar AnwarAli H Eid
Aug 18, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Alexander N Orekhov
Nov 16, 2020·Journal of Ethnopharmacology·Mueen Ahmad ChaudhryAsaad Mohamed Assiri
Jan 30, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Waqas YounisArquimedes Gasparotto Junior
Apr 4, 2021·International Journal of Molecular Sciences·Anna Bartáková, Marie Nováková
May 18, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Luísa Nathália Bolda MarianoPriscila de Souza

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