Involvement of brain-derived neurotrophic factor and sonic hedgehog in the spinal cord plasticity after neurotoxic partial removal of lumbar motoneurons

Neuroscience Research
Rosario Gulino, Massimo Gulisano

Abstract

Adult mammals could spontaneously achieve a partial sensory-motor recovery after spinal cord injury, by mechanisms including synaptic plasticity. We previously showed that this recovery is associated to the expression of synapsin-I, and that sonic hedgehog and Notch-1 could be also involved in plasticity. The role of brain-derived neurotrophic factor and glutamate receptors in regulating synaptic efficacy has been explored in the last decade but, although these mechanisms are now well-defined in the brain, the molecular mechanisms underlying the so called "spinal learning" are still less clear. Here, we measured the expression levels of choline acetyltransferase, synapsin-I, sonic hedgehog, Notch-1, glutamate receptor subunits (GluR1, GluR2, GluR4, NMDAR1) and brain-derived neurotrophic factor, in a motoneuron-depleted mouse spinal lesion model obtained by intramuscular injection of cholera toxin-B saporin. The lesion caused the down-regulation of the majority of analysed proteins. Moreover, we found that in lesioned but not in control spinal tissue, synapsin-I expression is associated to that of both brain-derived neurotrophic factor and sonic hedgehog, whereas GluR2 expression is linked to that of Shh. These results suggest t...Continue Reading

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Citations

Jun 13, 2015·BioMed Research International·Rosario GulinoMassimo Gulisano
Mar 29, 2019·International Journal of Molecular Sciences·Rosario GulinoRosalba Parenti
Mar 5, 2014·Journal of Anatomy·E De FeliceP Sordino
Apr 26, 2019·International Journal of Molecular Sciences·Nunzio VicarioRosario Gulino
Sep 19, 2019·Journal of Neuroscience Research·Surendra Kumar Anand, Amal Chandra Mondal
Mar 12, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Hao ZhangKlaus Zweckberger

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